The study of the impact of herbal medicinal products in soft dosage forms on the burn wound progression in the experiment
Keywords:herbal medicinal products, soft dosage form, burn wound, healing
The treatment of burns with topical preparations, namely ointments, which consist of herbal ingredients, becomes relevant among the population due to the fact that this dosage form is the most convenient to apply as self-medication; and biologically active substances that are part of these medicines are less toxic, and at the same time, they are not less effective than synthetic drugs against burn damages.
Aim. To study the wound-healing effect of drugs containing biologically active herbal ingredients using the model of burn wound.
Materials and methods. The study was conducted on 24 white female rats weighing 200-240 g. The experimental animals were divided into 4 groups: Group 1 – pathology (n = 6); Group 2 – animals treated with Wundahyl ointment (n = 6); Group 3 – animals treated with Spasatel Forte ointment (n = 6); Group 4 – animals treated with 2 % thiotriazoline ointment (n = 6).
Results. When treating the burn wounds with Wundahyl ointment and 2 % thiotriazoline ointment the wound-healing progression was better. The burn wound area for the following two weeks of observation (Days 14-21) decreased faster compared to the application of Spasatel Forte ointment and much faster in compared to the group of pathology. On Day 28, the burn wound was epithelized completely.
Conclusions. According to the results of the experiment, the effect of Wundahyl ointment was the most pronounced in relation to all the soft dosage forms under study.
Vazina, I. R. (2008). II sezd kombustiologov Rossii: sbornik nauchnyh trudov, 11–13.
Pysmenna, O. V. (2010). Ukraina. Zdorov’ia natsii, 2(14), 137–140.
Nikitina, N. V., Zatcepina, E. E., Khadzhieva, Z. D., Temirbulatova, A. M., Lezhneva, L. P., Nikitina, A. S., Pogrebniak, L. V. (2015). Sovremennye problemy nauki i obrazovaniia, 6.
Krutikov, M. G., Rakhaev, A. M. (2000). Kombustiologiia, 3, 36–38.
Iudin, V. (2011). Sovremennaia pediatriia, 3, 59–65.
Sean, C. (Ed.). (2009). Sweetman Martindale: The Complete Drug Reference. Thirty–sixth edition. Published by the Pharmaceutical Press, 3709.
Blatun, L. A. (2002). Farmatsevtycheskyi vestnyk, 3, 18–19.
Tkachuk, O. Yu., Vyshnevska, L. I., Markiv, V. I. (2012). Khimiia pryrodnykh spoluk: III Vseukrainska naukovo-praktychna konferentsiia (30-31.10. 2012). Ternopil, 137–138.
Vyshnevska, M. S., Kosiachenko, N. M., Vyshnevska, L. I. (2011). Zaporizkyi medychnyi zhurnal, 2, 53–57.
British Herbal Pharmacopoeia. (1996). British Herbal Medicine Association, Bristol, 212.
Yakovlieva, L. V., Tkachova, O. V., Butko, Ya. O., Lar’ianovska, Yu. B. (2013). Eksperymentalne vyvchennia novykh preparativ dlia mistsevoho likuvannia ran : metod. rek. DETs MOZ Ukrainy. Kyiv: DETs MOZ Ukrainy, 52.
Braun–Falco, O., Plewig, G., Wolff, H. H., Burgdorf, W. H. C. (2000). Dermatology, 2-nd ed. Berlin: Springer, 1853.
Bielenichev, I. F., Vizir, V. A., Mamchur, V. Y., & Kuriata, O. V. (2019). Place of tiotriazoline in the gallery of modern metabolitotropic medicines. Zaporozhye Medical Journal, 1, 118–128. https://doi.org/10.14739/2310-1210.2019.1.155856
Belai, I. M. (1997). «Aktualni pytanyia farmatsevtychnoi ta medychnoi nauky i praktyky», 1, 183–187.
Iermolenko, T. I., Kryvoshapka, O. V., & Pautina, O. I. (2018). Dynamics of the cytokine blood profile under the effect of wound
healing medicinal products with different mechanisms of action in the experiment. Klìnìčna Farmacìâ, 22(1), 44–49. https://doi.org/10.24959/cphj.18.1448
Viktorov, A. P. (2014). Compendium 2014 – Medicinal Products. Kyiv: Morion, 2448.
Zviahintseva, T. V., Kryvoshapka, O. V. (2010). 17. Patent №54891 Ukraina, MPK G09V 23/28. Prystrii dlia modeliuvannia termichnykh opikiv.
Zaikov, S. V. (2010). Dytiachyi likar, 2(4), 1–8.
Gliantc, S. (1999). Mediko-biologicheskaia statistika. Moscow: Praktika, 460.
Khalafian, A. A. (2007). STATISTICA 6. Statisticheskii analiz dannykh: uchebnik (3-edition). Moscow: OOO «Binom-Press», 512.
Copyright (c) 2019 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).