The serum levels of cytokines in thyroid heart failure patients

M. S. Zimina, O. O. Andrieieva, S. M. Zimin, K. M. Tkachenko


In recent years, the system of cytokines has a significant role in forming and progressing chronic heart failure of various etiologies (ischemic, inflammatory, infectious and allergic, etc.).

Aim. To study the activity of proinflammatory cytokines (interleukin-1α (Il-1α), interleukin-1β (Il-1β), interleukin-6 (Il-6) and interleukin-8 (Il-8) and anti-inflammatory cytokine (interleukin-4 (Il-4) in heart failure (HF) in thyrotoxicosis patients.

Materials and methods. 64 patients and 20 healthy volunteers were examined; they were distributed in 3 groups: group I (44 patients) patients with thyroid cardiomyopathy, group II (20) patients with no sign of cardiomyopathy and group III – 20 healthy volunteers. The serum levels of interleukines 1α, 1β, 4, 6 and 8 at admission, in 21 days and 6 months were measured.

Results. The level of IL-6 and IL-8 were significantly higher in patients with thyrotoxic HF compared to those without HF and healthy subjects. Correlation in Il-6 and Il-8 serum levels and severity and duration of HF were revealed. No correlation in Il-4 serum levels and HF was found.

Conclusions. It can be assumed that Il-6 and Il-8 are involved in the progression of heart failure and, less likely, in the formation of cardiomyopathy; however, for a more accurate identification of these regularities further studies are required.


interleukin; heart failure; thyroid toxicity; thyrotoxicosis; cytokines

Full Text:



Gianluigi, S., Lars, H. Lund. (2017). Global Public Health Burden of Heart Failure. Card Fail Rev, 3, 7–11.

Brickner, M. E., Hillis, L. D., & Lange, R. A. (2000). Congenital Heart Disease in Adults. New England Journal of Medicine, 342(4), 256–263.

Voronkov, L. H. (1999). Ukrainskyi kardiolohichnyi zhurnal, 1, 5–8.

Maggioni, A. P. (2001). HEART FAILURE: Treatment strategies for heart failure: beta blockers and antiarrhythmics. Heart, 85(1), 97–103.

Schmidt-Ott, U. M., & Ascheim, D. D. (2006). Thyroid hormone and heart failure. Current Heart Failure Reports, 3(3), 114–119.

Panchenkova, L. A., Troshina, E. A., Yurkova, T. E. (2000). Rossiyskie med. Vesti, 1, 18–25.

Efimov, A. S., Bodnar, P. N., Zelinskiy, B. A. (1983). Endokrinologiya. Kyiv, Vischa shkola, 47–52.

Gianoukakis, A. G., Khadavi, N., Smith, T. J. (2008). Cytokines, Graves’ Disease, and Thyroid-Associated Ophthalmopathy. Thyroid, 18, 953–958.

Liu, M., Chen, J., Huang, D., Ke, J., & Wu, W. (2014). A meta-analysis of proinflammatory cytokines in chronic heart failure. Heart Asia, 6(1), 130–136.

GOST Style Citations

1. Gianluigi, Savarese. Global Public Health Burden of Heart Failure / Gianluigi, Savarese, Lars. H. Lund // Card. Fail. Rev. – 2017. – Vol. 3. – P. 7–11.


2. Brickner, V. E. Congenital heart disease in adults: first of two parts / V. E. Brickner, L. D. Hillis, R. A. Lange // N. Engl. J. Med. – 2000. – Vol. 342. – P. 256–263.


3. Воронков, Л. Г. Изменения в сердце как основа прогрессирования сердечной недостаточности: основные механизмы / Л. Г. Воронков // Укр. кардіол. журн. – 1999. – № 1. – C. 5–8.


4. Maggioni, A. P. HEART FAILURE : Treatment strategies for heart failure : {beta}blockers and antiarrhythmics / A. P. Maggioni // Heart. – 2001. – Vol. 85. – P. 97–103.


5. Schmidt-Ott, U. M. Thyroid hormone and heart failure / U. M. Schmidt-Ott,D.D.Ascheim // Curr. Heart Fail. Rep. – 2006. – Vol. 3. – P. 114–119.


6. Панченкова, Л. А. Тиреоидный статус и сердечно-сосудистая система / Л. А. Панченкова, Е. А. Трошина, Т. Е. Юркова // Рос. мед. вести. – 2000. – № 1. – С. 18–25.


7. Ефимов, А. С. Эндокринология / А. С. Ефимов, П. Н. Боднар, Б. А. Зелинский. – К.: Вища школа, 1983. – С. 47–52.


8. Gianoukakis, A. G. Cytokines, Graves’ Disease, and Thyroid-Associated Ophthalmopathy / A. G. Gianoukakis, N. Khadavi, T. J. Smith // Thyroid. – 2008. – Vol. 18. – P. 953–958.


9. A meta-analysis of proinflammatory cytokines in chronic heart failure / M. Liu, J. Chen, D. Huang et al. // Heart Asia. – 2014. – Vol. 6 (1). – P. 130–136. 

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Abbreviated key title: Clin. pharm.

ISSN 2518-1572 (Online), ISSN 1562-725X (Print)