The study of the broncholytic effect of “Bronchosten” extract
DOI:
https://doi.org/10.24959/cphj.19.1500Keywords:
broncholytic ativity, bronchospasm, histamine, “Brochosten”Abstract
Despite the substantial progress achieved in prevention and treatment, acute respiratory diseases remain massively widespread with their share in the overall structure of infection diseases reaching 90–95 %. Therefore, the creation of new medicines for treating them persists in importance and relevance. Currently, the medicines of plant origin producing secretolytic and broncholytic effects perform sufficiently well. An advantage of herbal medicines compared to the synthetic ones is in their low toxicity; they do not give significant side effects with long-term use, and natural complexes of substances are close to the human body.
Аim. to study the broncholytic effect of a new “Bronchosten” extract developed at the Department of Pharmaceutical Drug Technology of theNationalUniversity of Pharmacy.
Materials and methods. The ability of the combined medicine under the conditional name “Bronchosten” to produce a bronchodilatory effect was studied on the model of acute bronchospasm induced by an aerosol intervention of 1 % histamine solution in guinea pigs.
Results. The broncholytic effect was assessed by the ability of the extract studied to reduce sneezing, coughing, and dyspnea compared to guinea pigs of the positive control group. The highest overall broncholytic activity was detected when “Bronchosten” extract was injected to the animals in the dose of 100 mg/kg. The effectiveness of this dose by its broncholytic effect was 10 % higher than the reference tablets “Bronchipret” in the theurapetic dose of 40 mg/kg.
Conclusions. Therefore, in the dose of 100 mg/kg “Brochosten” exhibits a substantial broncholytic effect at the level of 52.2 %, and this dose can be proposed for further study and creation of a new broncholytic medication.
References
Haluzeva zvitnist Derzhavnoi sanitarno-epidemiolohichnoi sluzhby Ukrainy (“Zvit pro okremi infektsiini ta parazytarni zakhvoriuvannia”, f. № 1). (n.d.). Available at: http://www.dsesu.gov.ua
2. European Pharmacopoeia 8.0. (2014). Strasbourg: Council ofEurope, 1275.
Maiko, D. V., Kukhtenko, O. S. (2014). Suchasni dosiahnennia farmatsevtychnoi tekhnolohii i biotekhnolohii: materialy IV nauk.– prakt. konf. z mizhnar. uchastiu. Kharkiv: NFaU, 193.
Koshoviy, O. M., Kukhtenko, O. S., Kovalova A. M., Komisarenko A. M. (2011). Farmatsevtichniy chasopis, 4, 39–42.
Kha Dyk, An., Kukhtenko, O. S., Gladukh. Ie. V. (2016). Development of technology for producing compound thick extract obtained by common extraction of thyme, yarrow, chamomile and eucalyptus. Topical issues of new drugs development : abstracts оf the XXIII-th international scientific and practical conference of young scientists and student, 1, 268.
Kukhtenko, O. S., Gladukh, I.V., & Simonian, L. S. (2017). Domestic market analysis of medicinal products for treatment of inflammatory respiratory diseases. Upravlìnnâ, ekonomìka ta zabezpečennâ âkostì v farmacìï, 4(52), 42–49. https://doi.org/10.24959/uekj.17.35
Khabriev, R. U. (Ed.). (2005). Rukovodstvo po eksperimentalnomu (doklinicheskomu) izucheniiu novykh farmakologicheskikh veshchestv (2-edition).Moscow: OAO «Izdatelstvo «Meditcina», 483–500.
Downloads
Published
Issue
Section
License
Copyright (c) 2019 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
