The study of the emotional and behavioral response in rats after introduction of the neogalenical phytocomplex from Ledum palustre shoots

Authors

  • K. S. Tolmachova National University of Pharmacy, Ukraine https://orcid.org/0000-0001-9248-2833
  • I. V. Kireyev National University of Pharmacy, Ukraine
  • O. M. Koshoviy National University of Pharmacy, Ukraine
  • K. V. Tsemenko National University of Pharmacy, Ukraine
  • I. V. Botsula National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/cphj.19.1499

Keywords:

neogalenical phytocomplex, Ledum palustre, “open field”, “elevated plus maze”

Abstract

While studying new medicinal products their effect on the central nervous system should be researched, namely the hypnotic and anxiolytic action of drugs should be determined. The results of the studies are necessary for further study of the drug and further preparation of the patient information leaflet.

Aim. To study emotional and behavioral responses in rats after introduction of the neogalenical phytocomplex from Ledum palustre shoots.

Materials and methods. The object of the study was the neogalenical phytocomplex from Ledum palustre shoots. The emotional and behavioral response was studied in two tests: “open field” and “elevated plus maze” in rats.

Results. According to the results of the study conducted the neogalenical phytocomplex from Ledum palustre shoots has no sedative, hypnotic, and anxiolytic effects.

Conclusions. Neogalenical phytocomplex from Ledum palustre shoots does not affect the central nervous system; therefore, theoretically, the effect of the complex studied on the ability to drive or work with other mechanisms is not expected in patients.

 

Author Biographies

K. S. Tolmachova, National University of Pharmacy

postgraduate student of the Department of Pharmacotherapy

I. V. Kireyev, National University of Pharmacy

Doctor of Medicine (Dr. habil), professor, head of the Department of Pharmacotherapy

O. M. Koshoviy, National University of Pharmacy

Doctor of Pharmacy (Dr. habil), professor, head of the Department of Pharmacognosy

K. V. Tsemenko, National University of Pharmacy

postgraduate student of the Department of Pharmacotherapy

I. V. Botsula, National University of Pharmacy

postgraduate student of the Department of Pharmacotherapy

References

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Published

2019-08-30

Issue

Section

Pre-clinical studies of new drugs