The effect of thick burdock extracts on development of model hyperplasia of the prostate gland in rats

Authors

  • C. G. Shchokina National University of Pharmacy
  • G. V. Belik National University of Pharmacy
  • T. O. Kutsenko National University of Pharmacy
  • D. V. Semeniv Ivano-Frankivsk National Medical University

DOI:

https://doi.org/10.24959/cphj.17.1433

Keywords:

thick burdock extracts, benign prostatic hyperplasia, prostatoprotective action, anti-inflammatory activity, antioxidant action

Abstract

Benign prostatic hyperplasia (BPHP) is one of the most common diseases in middle-aged and elderly men. In this regard, the search and study of new effective and safe medicines with the prostatoprotective effect is important and topical. For today, the nomenclature of domestic protostatotectors of the plant origin is limited.
Aim. To study experimentally the protoprotective properties of thick extracts of roots and leaves of common burdock on the model of sulpiride-induced prostatic hyperplasia in rats.
Materials and methods. The BPHP model reproduced the intraperitoneal administration of sulpiride to male rats in the dose of 40 mg/kg for 30 days. Thick burdock extracts in the dose of 75 mg/kg and the reference drug Prostaplant Forte in the dose of 35 mg/kg were administered intraperitoneally in the therapeutic regimen from day 31 to day 52 of the study.
Results. It has been proven that thick extracts of roots and leaves of burdock on the model of sulpiride-induced benign prostatic hyperplasia in rats reduce development of inflammatory processes, inhibit the processes of LPO, normalize the antioxidant / prooxidant balance in the animal’s body. Under the influence of these extracts the level of androgenic saturation of the body and the testosterone/estradiol ratio increase, indicating a positive effect of drugs on spermatogenesis. Thick extracts of burdock roots and leaves reduce the level of estradiol and dihydrotestosterone in the blood serum of the experimental animals, and it impedes development of proliferative processes in the prostate and inhibits development of the disease.
Conclusions. By the intensity of the prostatoprotective action thick extracts of roots and leaves of common burdock are not inferior to the reference drug Prostaplant Forte.

Author Biographies

C. G. Shchokina, National University of Pharmacy

Doctor of Pharmacy (Dr. habil.), professor of the Pharmacology Department

G. V. Belik, National University of Pharmacy

Candidate of Pharmacy (PhD), associate professor of the Pharmacology Department

T. O. Kutsenko, National University of Pharmacy

Candidate of Pharmacy (PhD), associate professor of the Pharmacology Department

D. V. Semeniv, Ivano-Frankivsk National Medical University

Doctor of Pharmacy (Dr. habil.), professor, head of the Department of Organization and Economics of Pharmacy and Drug Technology

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Published

2017-09-14

Issue

Section

Pre-clinical studies of new drugs