The study of the anti-exudative action of the combined cream-gel with glucosamine hydrochloride, hondroitine sulfate, camphora and menthol in the experiment
DOI:
https://doi.org/10.24959/cphj.17.1432Keywords:
inflammation, cream-gel, glucosamine hydrochloride, anti-exudative action, carrageenin, zymosan, serotonin, histamineAbstract
Osteoarthritis (OA) is a severe degenerative-dystrophic joint disease. Treatment of OA should be complex with the use of painkillers, anti-inflammatory and chondroprotective agents. The original combined cream-gel with glucosamine hydrochloride, chondroitin sulfate, camphore and menthol meets these requirements.
Aim. To study the anti-exudative effect of the original combined cream-gel.
Materials and methods. The anti-exudative effect of the cream-gel was studied on the models of exudative inflammation caused by carrageenin (1 % solution), zymosan (2 %), histamine (0.25 %) and serotonin (0.5 %) in rats.
Results. The presence of the expressed anti-excudative effect on different inflammatory models by the level of antiinflammatory activity has been proven: carrageenan – 43.71 %, zymosanic – 32.83 %, serotonin – 24.04 %, histamine – 38.4 %. The results of studying the effect of the cream-gel under research on the inflammatory process with a predominantly exudative component on the models of acute carrageenan, zymosan, histamine, serotonin edema in experimental animals indicate the presence of an anti-exudative component in the cream-gel studied; it is somewhat inferior to the anti-inflammatory effect of diclofenac sodium. Based on the results of the experiments conducted it can be assumed that the anti-inflammatory effect is due to effect on the activity of pro-inflammatory biologically active substances – prostaglandins and leukotrienes, as well as the presence of membrane-stabilizing properties in the components of the cream-gel.
Conclusions. The presence of the anti-exudative action together with the data on the antinociceptive and chondroprotective action given in our previous works will promote to increase the effectiveness of treatment of such a serious joint disease as OA.
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