The experimental study of anti-inflammatory properties of the drug “Diclocor”


  • O. S. Popov National University of Pharmacy, Ukraine
  • S. K. Shebeko National University of Pharmacy, Ukraine
  • O. I. Shevchenko National University of Pharmacy, Ukraine
  • A. S. Shalamay National University of Pharmacy, Ukraine



Diclocor, diclofenac, quercetin, inflammation


Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used groups of medicines. Despite the undeniable clinical effectiveness, their use is associated with the risk of side effects. This fact directs scientific research to searching combinations of NSAIDs with other substances in order to identify compositions which will allow reducing the dose of the NSAID without losing its anti-inflammatory effectiveness. In view of all this, a new combined drug “Diclocor” developed by “Borshchahivskiy CPP” (Ukraine) is of interest. The article presents the results of the experimental study of the anti-inflammatory effect of the combined drug “Diclocor” in comparison with its active monocomponents – diclofenac sodium and quercetin. The alterative stage of inflammation was studied on the model of scarified wounds, the exudative stage – on the model of carrageenin edema, and the proliferative stage – on the model of cotton pellet-induced granuloma. All studies were conducted in rats. The experimental results have shown the superiority of Diclocor in influencing on all three stages of inflammation compared to the reference drugs in the appropriate doses. Diclocor has exhibited the most pronounced effect on the stages of alteration and exudation, and can be described as a promising drug for the treatment of proliferative and destructive inflammatory diseases.


Коваленко В.М., Борткевич О.П., Проценко Г.О. Нестероидные противовоспалительные препараты: роль и место в современной ревматологической практике на основании доказательной медицины // Украинский ревматологический журнал.– 2006.– Т. 23, № 1.– С. 17-29.

Ковалев В.Б., Ковган В.В., Колчина Е.Ю. Механизмы лечебного действия биофлавоноида кверцетина (обзор литературы) // Український медичний аль-манах.– 1999.– Т. 2, № 4.– С. 176-182.

Лапач С.Н. Статистические методы в медико-биологических исследовани-ях с использованием Excel // С. Н. Лапач, А. В. Чубенко, П. Н. Бабич.– К.: Морион, 2000.– 320 с.

Миронов А.Н., Бунатян Н.Д. и др. Руководство по проведению доклиниче-ских исследований лекарственных средств. Часть первая.– М.: Гриф и К, 2012.– 944 с.

Прозоровский В.Б. Практическое пособие по ускоренному определению средних эффективных доз и концентрации биологически активных веществ // Прозоровский. В.Б.– СПб, 1992. – 42 с.

Стефанова А.В. Доклинические исследования лекарственных средств: Методические рекомендации // Под ред. Стефанова. А.В.– К: Авиценна, 2002.– 528 с.

Стефанов О., Бухтіарова Т., Коваленко В. та ін. Настанова СТ-Н МОЗУ 42-6.0:2008. Лікарські засоби. Належна лабораторна практика (видання офіційне) // К.: Моріон, 2009.– С. 37-68.

Chi-Yu Y., Su-Lan H., Kuo-Ching W. et al. Bioavailability and Metabolitic Pharmacokinetics of Rutin and Quercetin in Rats // Journal of Food and Drug Analysis.– 2005.– Vol. 13.– P. 244-250.

Das N. et al. Quercetin alleviates inflammation after short-term treatment in high-fat-fed mice // Food & Function.– 2013.– Vol. 4(6). – P. 889–898. Available at:

Gardi C. et al. Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis // Archives of biochemistry and biophysics. – 2015. – Vol. 583. – P. 150–157.

Marcolin E. et al. Quercetin Treatment Ameliorates Inflammation and Fibrosis in Mice with Nonalcoholic Steatohepatitis. The Journal of Nutrition.– 2012.– Vol. 142(10) .– P.1821–1828.

Rogerio A.P. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma // Inflamm. Res.– 2007.– Vol. 56.– P. 402-408.





Pre-clinical studies of new drugs