The experimental study of pharmacological properties of the Phallus impudicus tincture

Authors

DOI:

https://doi.org/10.24959/cphj.20.1532

Keywords:

Phallus impudicus tincture, gastroprotective effect, anti-inflammatory effect, analgesic effect

Abstract

The study of properties of higher fungi, which are a potential source of biologically active substances, is a necessary vector for creating drugs with prophylactic and therapeutic purposes based on fungi and products of their metabolism.

Aim. To study experimentally the anti-inflammatory, analgesic, anti-ulcer effects and the impact on the intestinal peristalsis of the Phallus impudicus (common stinkhorn) tincture.

Materials and methods. The research object is the Phallus impudicus tincture with 40% ethyl alcohol in the ratio of 1:5. The conventional therapeutic dose was determined in screening studies on the model of the rat gastric lesion with acetylsalicylic acid. The anti-inflammatory effect was studied on models of carrageenan and zymosan foot edemas in rats in the dose of 0.3 ml/kg, while the analgesic effect was observed on models of acetic acid-induced writhings in mice. The effect of the tincture on the intestinal motility in the dose of 0.4 ml/kg was also studied.

Results. Experiments on rats have shown that the Phallus impudicus tincture in the dose of 0.3 ml/kg exhibits the anti-ulcer effect, reducing the gastric mucosa damage by acetylsalicylic acid. The tincture has no effect on the intestinal peristalsis. The anti-inflammatory effect was observed only on the model of carrageenan edema; zymosan-induced edema did not reduce. It indicates the fungus dominance over prostaglandins synthesis. The tincture has a pronounced analgesic effect on the model of acetic acid-induced writhings in mice.

Conclusions. The results of the study indicate that the tincture of Phallus impudicus has a pronounced anti-inflammatory, analgesic, gastroprotective effects, and does not affect the intestinal motility.

Author Biographies

T. I. Iermolenko, Kharkiv National Medical University

Doctor of Pharmacy (Dr. habil.), professor, head of the Department of Pharmacology and Medical Prescription

N. S. Chorna, Kharkiv National Medical University

Candidate of Pharmacy (Ph.D.), teaching assistant of the Department of Pharmacology and Medical Prescription

O. V. Krivoshapka, Kharkiv National Medical University

Candidate of Medicine (Ph.D.), associate professor of the Department of Pharmacology and Medical Prescription

O. V. Vlasenko, Kharkiv National Medical University

6th year student, 3rd medical faculty, 3rd group

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Published

2020-09-03

Issue

Vol. 24 No. 3 (2020)

Section

Pre-clinical studies of new drugs

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