The experimental study of pharmacological properties of the Phallus impudicus tincture
Keywords:Phallus impudicus tincture, gastroprotective effect, anti-inflammatory effect, analgesic effect
The study of properties of higher fungi, which are a potential source of biologically active substances, is a necessary vector for creating drugs with prophylactic and therapeutic purposes based on fungi and products of their metabolism.
Aim. To study experimentally the anti-inflammatory, analgesic, anti-ulcer effects and the impact on the intestinal peristalsis of the Phallus impudicus (common stinkhorn) tincture.
Materials and methods. The research object is the Phallus impudicus tincture with 40% ethyl alcohol in the ratio of 1:5. The conventional therapeutic dose was determined in screening studies on the model of the rat gastric lesion with acetylsalicylic acid. The anti-inflammatory effect was studied on models of carrageenan and zymosan foot edemas in rats in the dose of 0.3 ml/kg, while the analgesic effect was observed on models of acetic acid-induced writhings in mice. The effect of the tincture on the intestinal motility in the dose of 0.4 ml/kg was also studied.
Results. Experiments on rats have shown that the Phallus impudicus tincture in the dose of 0.3 ml/kg exhibits the anti-ulcer effect, reducing the gastric mucosa damage by acetylsalicylic acid. The tincture has no effect on the intestinal peristalsis. The anti-inflammatory effect was observed only on the model of carrageenan edema; zymosan-induced edema did not reduce. It indicates the fungus dominance over prostaglandins synthesis. The tincture has a pronounced analgesic effect on the model of acetic acid-induced writhings in mice.Conclusions. The results of the study indicate that the tincture of Phallus impudicus has a pronounced anti-inflammatory, analgesic, gastroprotective effects, and does not affect the intestinal motility.
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