The experimental study of pharmacological properties of the Phallus impudicus tincture
Keywords:Phallus impudicus tincture, gastroprotective effect, anti-inflammatory effect, analgesic effect
The study of properties of higher fungi, which are a potential source of biologically active substances, is a necessary vector for creating drugs with prophylactic and therapeutic purposes based on fungi and products of their metabolism.
Aim. To study experimentally the anti-inflammatory, analgesic, anti-ulcer effects and the impact on the intestinal peristalsis of the Phallus impudicus (common stinkhorn) tincture.
Materials and methods. The research object is the Phallus impudicus tincture with 40% ethyl alcohol in the ratio of 1:5. The conventional therapeutic dose was determined in screening studies on the model of the rat gastric lesion with acetylsalicylic acid. The anti-inflammatory effect was studied on models of carrageenan and zymosan foot edemas in rats in the dose of 0.3 ml/kg, while the analgesic effect was observed on models of acetic acid-induced writhings in mice. The effect of the tincture on the intestinal motility in the dose of 0.4 ml/kg was also studied.
Results. Experiments on rats have shown that the Phallus impudicus tincture in the dose of 0.3 ml/kg exhibits the anti-ulcer effect, reducing the gastric mucosa damage by acetylsalicylic acid. The tincture has no effect on the intestinal peristalsis. The anti-inflammatory effect was observed only on the model of carrageenan edema; zymosan-induced edema did not reduce. It indicates the fungus dominance over prostaglandins synthesis. The tincture has a pronounced analgesic effect on the model of acetic acid-induced writhings in mice.Conclusions. The results of the study indicate that the tincture of Phallus impudicus has a pronounced anti-inflammatory, analgesic, gastroprotective effects, and does not affect the intestinal motility.
Vishnevskii, M. V. (2014). Lekarstvennye griby. Bolshaia entciklopediia. Moscow : Eksimo, 400.
Vasser, S. P. (Ed.). (2011). Biologicheskie osobennosti lekarstvennykh makromitcetov v kulture. (Vols. 1-2. Vol. 1). Kiev : Alterpres, 212.
Luzіna, D. V. (2017). Problemy ekolohіchnoi bіotehnolohіi, 1. Available at: http://nbuv.gov.ua/UJRN/peb_2017_1_11.
Prozorova, L. A., Rebriev, Yu. A., Ternovenko, V. A. (2018). BIOTA and ENVIRONMENT, 3, 48–53. Available at: http://biota-environ.com/position.html.
Sitinjak, Rama R. (2016). Analysis of the morphology and growth of the fungus Phallus indusiatus Vent in Cocoa Plantation, Gaperta-Ujung Medan. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7 (6), 442–449. Available at: https://www.rjpbcs.com/pdf/2016_7(6)/.pdf.
Puchkova, T. A., Osadchaia, O. V., Kostenevich, A. A., Buko, V. U. (2016). Vestsі Natsyiyanalnay akademіі navuk Belarusі. Seryiya bіyalagіchnyih navuk, 1, 13–16.
Тeplyakova, Т., Kosogova, Т. (2015). Fungal Bioactive Compounds with Antiviral Effect. Journal of Pharmacy and Pharmacology, 3, 357–371. Available at: https://www.academia.edu/39268176/.
Gupta, A, Shinde, B. (2016). Immunopharmacological evaluation of Phallus impudicus against specific protein antigen. MicroMed., 4 (2), 55–59. Available at: https://www.academia.edu/37165870/4.pdf.
Sari, М., Prange, A., Lelley, J. I., Hambitzer, R. (2017). Screening of beta-glucan contents in commercially cultivated and wild growing mushrooms. Food Chemistry, 216, 45–51. Available at: https://www.semanticscholar.org/.
Sticknay, J. S., Van Liere, E. J., Narthup, D. W. (1951). Correllation between progressive motility and length of the small-intestine in albino rats and dogs. Amer. J. Physiol., 167 (2), 399-402. doi: https://doi.org/10.1152/ajplegacy.19184.108.40.2069.
Zaharevskii, A. S. (1962). Vliianie nekotoryh proizvodnyh indola na nervnuiu sistemu. Candidate’s thesis. Minsk. Available at: http://nbuv.gov.ua/j-pdf/flt_2014_4-5_8.pdf.
Liapunov, N. A., Zahorii, V. A., Heorhievskii, V. P., Bezuhla, E. P. (Eds). (1999). Nadlezhashchaia proizvodstvennaia praktika lekarstvennykh sredstv. Kiev : Morion, 508–545.
Copyright (c) 2020 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).