The study of the acute toxicity and the laxative effect of pectins from Pimpinella anisum herb
DOI:
https://doi.org/10.24959/cphj.20.1528Keywords:
Pimpinella anisum, pectins, acute toxicity, laxative effectAbstract
The modern pharmaceutical market offers a large number of drugs that promote the act of defecation. But at the same time medicinal plants should not be neglected in the treatment of constipation. Biologically active substances contained in them in their natural proportions may have a higher physiological effect with long-term use than their individual ingredients in patented drugs.
Aim. To study the acute toxicity and the laxative effect of pectins isolated from Pimpinella anisum herb.
Materials and methods. The acute toxicity of pectins isolated from Pimpinella anisum herb was determined in rats under conditions of a single intragastric injection. The laxative effect was studied in white rats compared to the drug “Senadex”. The percentage of increase in feces was determined as a criterion of the laxative effect.
Results. After a single intragastric administration of the drug studied in the dose of 5000 mg/kg the death among animals was not observed. Pectins isolated from Pimpinella anisum herb in the test dose significantly increase the amount of fecal mass in animals by 88% compared to the control and are not inferior to the laxative effect of the reference drug “Senadex”.
Conclusions. Pectin substances isolated from Pimpinella anisum herb are virtually non-toxic, have a pronounced laxative effect and can be used as a medicinal substance when creating drugs of this action.References
Tumarenko, A. V., Skvortcov, V. V. (2016). Sovremennye podkhody k farmakoterapii zaporov. Meditcinskii sovet, 5, 80–83.
Boskabady, M. ., & Ramazani-Assari, M. (2001). Relaxant effect of Pimpinella anisum on isolated guinea pig tracheal chains and its possible mechanism(s). Journal of Ethnopharmacology, 74(1), 83–88. https://doi.org/10.1016/s0378-8741(00)00314-7
Pourgholami, M. ., Majzoob, S., Javadi, M., Kamalinejad, M., Fanaee, G. H. ., & Sayyah, M. (1999). The fruit essential oil of Pimpinella anisum exerts anticonvulsant effects in mice. Journal of Ethnopharmacology, 66(2), 211–215. https://doi.org/10.1016/s0378-8741(98)00161-5
Soliman, K., & Badeaa, R. (2002). Effect of oil extracted from some medicinal plants on different mycotoxigenic fungi. Food and Chemical Toxicology, 40(11), 1669–1675. https://doi.org/10.1016/s0278-6915(02)00120-5
Park, I.-K., Choi, K.-S., Kim, D.-H., Choi, I.-H., Kim, L.-S., Bak, W.-C., … Shin, S.-C. (2006). Fumigant activity of plant essential oils and components from horseradish (Armoracia rusticana), anise (Pimpinella anisum) and garlic (Allium sativum) oils againstLycoriella ingenua (Diptera: Sciaridae). Pest Management Science, 62(8), 723–728. https://doi.org/10.1002/ps.1228
Conforti, F., Tundis, R., Marrelli, M., Menichini, F., Statti, G. A., De Cindio, B., … Houghton, P. J. (2010). Protective Effect of Pimpinella anisoides Ethanolic Extract and Its Constituents on Oxidative Damage and Its Inhibition of Nitric Oxide in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages. Journal of Medicinal Food, 13(1), 137–141. https://doi.org/10.1089/jmf.2008.0154
Cengiz, N., Özbek, H., Him, A. (2008). Hepatoprotective Effects of Pimpinella anisum Seed Extract in Rats. Pharmacologyonline, 3, 870–874.
Gülçın, İ., Oktay, M., Kıreçcı, E., & Küfrevıoǧlu, Ö. İ. (2003). Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts. Food Chemistry, 83 (3), 371–382. https://doi.org/10.1016/s0308-8146(03)00098-0
Belenkii, M. L. (1963). Elementy kolichestvennoi otcenki farmakologicheskogo effekta. Leningrad: Medgiz, 152.
Shmygareva, A. A., Kurkin, V. A., Sankov, A. N. (2015). Sravnitelnoe issledovanie slabitelnogo deistviia preparatov, soderzhashchikh antraglikozidy. Meditcinskii almanakh, 3, 220–222.
Downloads
Published
Issue
Section
License
Copyright (c) 2020 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).