The study of the acute toxicity and the laxative effect of pectins from Pimpinella anisum herb

Authors

  • S. V. Kolisnyk National University of Pharmacy, Ukraine https://orcid.org/0000-0002-4920-6064
  • U. A. Umarov National University of Pharmacy, Ukraine https://orcid.org/0000-0001-8981-5908
  • K. V. Dynnyk National University of Pharmacy, Ukraine
  • M. Fathullaeva Tashkent Pharmaceutical Institute, Uzbekistan
  • A. A. Shabilalov Tashkent Pharmaceutical Institute, Uzbekistan
  • A. S. Gazieva Tashkent Pharmaceutical Institute, Uzbekistan

DOI:

https://doi.org/10.24959/cphj.20.1528

Keywords:

Pimpinella anisum, pectins, acute toxicity, laxative effect

Abstract

The modern pharmaceutical market offers a large number of drugs that promote the act of defecation. But at the same time medicinal plants should not be neglected in the treatment of constipation. Biologically active substances contained in them in their natural proportions may have a higher physiological effect with long-term use than their individual ingredients in patented drugs.

Aim. To study the acute toxicity and the laxative effect of pectins isolated from Pimpinella anisum herb.

Materials and methods. The acute toxicity of pectins isolated from Pimpinella anisum herb was determined in rats under conditions of a single intragastric injection. The laxative effect was studied in white rats compared to the drug “Senadex”. The percentage of increase in feces was determined as a criterion of the laxative effect.

Results. After a single intragastric administration of the drug studied in the dose of 5000 mg/kg the death among animals was not observed. Pectins isolated from Pimpinella anisum herb in the test dose significantly increase the amount of fecal mass in animals by 88% compared to the control and are not inferior to the laxative effect of the reference drug “Senadex”.

Conclusions. Pectin substances isolated from Pimpinella anisum herb are virtually non-toxic, have a pronounced laxative effect and can be used as a medicinal substance when creating drugs of this action.

Author Biographies

S. V. Kolisnyk, National University of Pharmacy

Doctor of Pharmacy (Dr.habil.), professor of the Department of Analytical Chemistry

U. A. Umarov, National University of Pharmacy

postgraduate student of the Department of Analytical Chemistry

K. V. Dynnyk, National University of Pharmacy

Candidate of Pharmacy (PhD), associate professor of the Department of Analytical Chemistry

M. Fathullaeva, Tashkent Pharmaceutical Institute

Candidate of Chemistry (PhD), associate professor, head of the Department of Analytical Chemistry

A. A. Shabilalov, Tashkent Pharmaceutical Institute

Doctor of Chemistry (Dr.habil.), professor of the Department of Analytical Chemistry

A. S. Gazieva, Tashkent Pharmaceutical Institute

teaching assistant of the Department of Analytical Chemistry

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Published

2020-06-03

Issue

Vol. 24 No. 2 (2020)

Section

Pre-clinical studies of new drugs

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