Clinical and pharmaceutical features of using phytoneering medicines in the nefrological profile patients




pathology of the urinary system, treatment, metaphylaxis, the drug “Canephron® N”, multivector pharmacodynamics, evidence-based medicine and pharmacy


According to the WHO the pathology of the urinary system affects the population of different ages and averages 10 % of the total population in the world. Today, in the domestic healthcare system there are about 500 thousand patients with chronic kidney disease, which is one of the most socially significant pathologies. The increase in the prevalence of urinary system diseases is primarily associated with a significant prevalence of diabetes mellitus, arterial hypertension and obesity, environmental degradation and uncontrolled drug use. Pathological changes in the kidneys also cause malnutrition, bad habits. The impaired renal function and other organs of the urinary system signal the body with many different symptoms, which are often disguised as symptoms of other diseases. That is why a person who first encounters manifestations of nephro- or uropathology does not always give them a serious meaning and begins to apply various treatment methods under his/her own responsibility, as opposed to responsible self-medication. The danger of this situation is that turning to the pharmacy a visitor focuses on the symptom that worries him/her most (most often it is pain in the lower back, lower abdomen, fever), and does not attach importance to other indicator symptoms of pathology. As part of pharmaceutical care the primary task of a pharmacist is to correctly assess the state of the pharmacy visitor taking into account both the nature and totality of his/her complaints, and the timely detection of “alarm” manifestations of urinary system diseases.

Nephro- and urology today is a branch of practical medicine, in which the use of herbal medicines is substantiated from the point of view of clinical pharmacology. And, if in acute forms of diseases their use is auxiliary, then in chronic diseases their role significantly increases. When carrying out metaphylaxis (anti-relapse treatment) for urinary tract infections and, especially, nephrolithiasis, herbal medicines are indispensable today. When choosing a drug for metaphylaxis of nephro- and uropathology a responsible professional in medicine and pharmacy will be guided by the data of evidence-based medicine as the highest determining category in the process of the rational pharmacotherapy, and a competent consumer in the framework of responsible self-medication should choose a drug with the greatest degree of trust (the brand recognition is determined, among other things, by consistently high quality). Thus, for the prevention and treatment of urinary system diseases the drug “Canephron® N” with the multivector pharmacodynamics, namely the diuretic, antispasmodic, anti-inflammatory, antibacterial, nephroprotective and antiplatelet action, has a significant evidence base.

Conclusions. The drug “Canephron® N” is an alternative choice for the treatment and prevention of patients with urinary tract diseases.

Author Biographies

I. A. Otrishko, National University of Pharmacy

Candidate of Medicine (Ph.D.), associate professor of the Department of Clinical Pharmacology and Clinical Pharmacy

S. K. Shebeko, National University of Pharmacy

PhD, assistant professor of the clinical pharmacology and clinical pharmacy department

N. P. Bezugla, National University of Pharmacy

Candidate of Pharmacy (Ph.D.), associate professor of the Department of Clinical Pharmacology and Clinical Pharmacy


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Clinical Pharmacology and Pharmacotherapy