The photoprotective action of “Salizink” cream on the model of photodynamic injury in rats

Authors

DOI:

https://doi.org/10.24959/cphj.20.1513

Keywords:

dermatitis, white willow bark, photoprotective activity, zinc pyrithionate, inflammation

Abstract

Ultraviolet (UV) radiation, which almost the entire population of the planet is exposed to, is an etiopathogenetic factor in many diseases, including photodermatitis, sunburn, photoaging, carcinogenesis, photoallergy, etc. The use of photoprotective drugs and cosmetic products, which active pharmaceutical ingredients (AFIs) absorb or repel UV rays, helps to reduce the negative impact of sunlight on the body.

Therefore, it is advisable to search and study new photoprotectors that can not only absorb or reflect the UV rays of a particular area of the spectrum, but also able to protect against broad-spectrum radiation.

Аim. To study the photoprotective activity (PPA) of a new cream based on the composition of Salix alba L. bark and zinc pyrithionate conditionally named “Salizink” on the model of acute photodynamic inflammation of the skin in rats. “Psoricap” cream was chosen as a reference drug.

Materials and methods. The photoprotective activity of “Salizink” cream was studied on the model of photodynamic injury caused by UV irradiation in rats.

Results. The study has found that photodynamic inflammation of the skin developed gradually. On the background of the treatment with “Salizink” cream a significant decrease in the intensity of photodynamic inflammation of the skin of animals characterized by reduction of edema and hyperemia, as well as a decrease in the skinfold thickness were observed compared to the control pathology group (CP

Conclusions. The results of the study indicate that “Salizink” cream on the model of photodynamic UV-induced skin injury has shown marked anti-inflammatory properties. Its use has reduced the intensity of acute photodynamic inflammation and accelerated the recovery of experimental animals. The results obtained substantiate the feasibility of further study of “Salizink” cream as a photoprotective agent for the treatment of contact allergic dermatitis.

Author Biographies

L. M. Maloshtan, National University of Pharmacy

Doctor of Biology (Dr. habil.), professor, head of the Physiology and Human Anatomy Department

V. V. Pidhaina, National University of Pharmacy

postgraduate student of the Department of Human Physiology and Anatomy

Ye. V. Gladukh, National University of Pharmacy

Doctor of Pharmacy (Dr. habil.), professor of the Industrial Pharmacy Department

Yu. S. Taranenko, National University of Pharmacy

postgraduate student of the Industrial Pharmacy Department

O. M. Shatalova, National University of Pharmacy

Candidate of Medicine (Ph.D.), associate professor of the Department of Human Physiology and Anatomy

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Published

2020-03-06

Issue

Vol. 24 No. 1 (2020)

Section

Pre-clinical studies of new drugs

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