DOI: https://doi.org/10.24959/cphj.20.1513

The photoprotective action of “Salizink” cream on the model of photodynamic injury in rats

L. M. Maloshtan, V. V. Pidhaina, Ye. V. Gladukh, Yu. S. Taranenko, O. M. Shatalova

Abstract


Ultraviolet (UV) radiation, which almost the entire population of the planet is exposed to, is an etiopathogenetic factor in many diseases, including photodermatitis, sunburn, photoaging, carcinogenesis, photoallergy, etc. The use of photoprotective drugs and cosmetic products, which active pharmaceutical ingredients (AFIs) absorb or repel UV rays, helps to reduce the negative impact of sunlight on the body.

Therefore, it is advisable to search and study new photoprotectors that can not only absorb or reflect the UV rays of a particular area of the spectrum, but also able to protect against broad-spectrum radiation.

Аim. To study the photoprotective activity (PPA) of a new cream based on the composition of Salix alba L. bark and zinc pyrithionate conditionally named “Salizink” on the model of acute photodynamic inflammation of the skin in rats. “Psoricap” cream was chosen as a reference drug.

Materials and methods. The photoprotective activity of “Salizink” cream was studied on the model of photodynamic injury caused by UV irradiation in rats.

Results. The study has found that photodynamic inflammation of the skin developed gradually. On the background of the treatment with “Salizink” cream a significant decrease in the intensity of photodynamic inflammation of the skin of animals characterized by reduction of edema and hyperemia, as well as a decrease in the skinfold thickness were observed compared to the control pathology group (CP

Conclusions. The results of the study indicate that “Salizink” cream on the model of photodynamic UV-induced skin injury has shown marked anti-inflammatory properties. Its use has reduced the intensity of acute photodynamic inflammation and accelerated the recovery of experimental animals. The results obtained substantiate the feasibility of further study of “Salizink” cream as a photoprotective agent for the treatment of contact allergic dermatitis.


Keywords


dermatitis; white willow bark; photoprotective activity; zinc pyrithionate; inflammation

References


Sidorovich, O. I., & Tsyvkina, E. A. (2018). Photodermatoses: prevention and treatment. Medical Council, (12), 132–134. https://doi.org/10.21518/2079-701X-2018-12-132-134

Fitcpatrik, T., Dzhonson, R., Vulf, K., Polano, M., Siurmond, D. (1999). Dermatologiia: atlas-spravochnik. Moscow: Praktika, 1088.

Akimov, V. G. (2008). Vestnik dermatologii i venerologii, 3, 81–84.

Maalouf, D., Battistella, M., & Bouaziz, J.-D. (2015). Neutrophilic dermatosis. Current Opinion in Hematology, 22(1), 23–29. https://doi.org/10.1097/moh.0000000000000100

Ernandes, E. I., Margolina, A. A. (2012). Novaia kosmetologiia. Osnovy sovremennoi kosmetologii. Moscow: OOO «ID «Kosmetika i meditcina», 600.

Zaichenko, A. V., Pokotilo, O. A. (2018). Retcept, 21(5), 658–667.

Junkins-Hopkins, J. M., Busam, K. (Eds.). (2016). Blistering Skin Diseases. In Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series, (2nd edition). Elsevier Health Sciences, Philadelphia, PA, 207–248.

Zuzuk, B. M., Kutcik, R. V., Nedostup, A. T., Khomenetc, I. Z., Permiakov, V. V. (2005). Provizor, 15, 16, 17, 16–18; 27–29; 31–36.

Khlebnikova, A. N., Petrunin, D. D. (2013). Vestnik dermatologii i venerologii, 6, 100–116.

Lansdown, A. B. G., Mirastschijski, U., Stubbs, N., Scanlon, E., & Ågren, M. S. (2007). Zinc in wound healing: Theoretical, experimental, and clinical aspects. Wound Repair and Regeneration, 15(1), 2–16. https://doi.org/10.1111/j.1524-475x.2006.00179.x

Institute of Laboratory Animal Resources (US). Committee on Care, Use of Laboratory Animals, & National Institutes of Health (US). Division of Research Resources. (1985). Guide for the care and use of laboratory animals.

Order of the Ministry of Healthcare of Ukraine. (2009). “Procedure for conducting pre-clinical study of drugs and examination of materials for preclinical study of drugs”. No. 944 dated 14.12. Available at: https://zakon.rada.gov.ua/laws/show/z0053-10


GOST Style Citations


1. Сидорович, О. И. Фотодерматозы : профилактика и лечение / О. И. Сидорович, Е. А. Цывкина // Мед. совет. – 2018. – № 12. – С. 132–134. https://doi.org/10.21518/2079-701X-2018-12-132-134


2. Дерматология : атлас-справочник / Т. Фицпатрик, Р. Джонсон, К. Вулф и др. – М. : Практика, 1999. – 1088 с.


3. Акимов, В. Г. Биологические эффекты ультрафиолетового облучения кожи / В. Г. Акимов // Вестник дерматол. и венерол. – 2008. – № 3. – С. 81–84.


4. Maalouf, D. Neutrophilic dermatosis: disease mechanism and treatment / D. Maalouf, M. Battistella, J. D. Bouaziz // Curr. Opin. Hematol. – 2015. – Vol. 22 (1). – P. 23–29. https://doi.org/10.1097/moh.0000000000000100


5. Эрнандес, Е. И. Новая косметология. Основы современной косметологии / Е. И. Эрнандес, А. А. Марголина. – М. : ООО «ИД «Косметика и медицина», 2012. – 600 с.


6. Зайченко, А. В. Изучение фотопротекторной активности крема с наночастицами диоксида церия на модели усиленной аммифурином фотодинамической травмы у морских свинок / А. В. Зайченко, О. А. Покотило // Рецепт. – 2018. – Т. 21, № 5. – С. 658–667.


7. Junkins-Hopkins, J. M. Blistering skin diseases / J. M. Junkins-Hopkins, K. Busam. – Dermatopathology. Philadelphia : Saunders, 2016. – P. 207–248.


8. Ива белая Salixalba L. (Аналитический обзор) // Б. М. Зузук, Р. В. Куцик, А. Т. Недоступ и др. // Провизор. – 2005. – № 15, 16, 17. – С. 16–18; 27–29; 31–36.


9. Хлебникова, А. Н. Цинк, его биологическая роль и применение в дерматологии / А. Н. Хлебникова, Д. Д. Петрунин // Вестник дерматол. и венерол. – 2013. – № 6. – С. 100–116.


10. Zinc in wound healing: theoretical, experimental, and clinical aspects / A. B. Lansdown, U. Mirastschijski, N. Stubbs et al. // WoundRepairRegen. – 2007. – Vol. 15 (1). – P. 2–16. https://doi.org/10.1111/j.1524-475x.2006.00179.x


11. Institute of Laboratory Animal Resources (US). Committee on Care, Use of Laboratory Animals, & National Institutes of Health (US). Division of Research Resources. Guide for the care and use of laboratory animals. – 1995.


12. Order of the Ministry of Healthcare of Ukraine. “Procedure for conducting pre-clinical study of drugs and examination of materials for preclinical study of drugs”. – 2009. – № 944 dated 14.12. – Available at : https://zakon.rada.gov.ua/laws/show/z0053-10





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Abbreviated key title: Clin. pharm.

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