Statins: pharmacoeconomic aspects of the use of hmg-coa reductase inhibitors




HMG-CoA reductase inhibitors, medicines, pharmaceutical market, affordability


Big hopes for reducing high mortality from cardiovascular diseases are placed on statins, the use of which is due to the effective action of the drugs, broad indications,  a prolonged and positive experience of use, and a high evidence base.

Purpose. The aim of the work was the formation of a modern understanding of the market structure and analysis of the availability of HMG-CoA reductase inhibitors.

Materials and methods. The studies were conducted in accordance with the State Register of Medicinal Products of Ukraine, ATC-classification, Equalizer system data. The study was performed by statistical, logical and graphical methods, as well as methods of marketing analysis.

Results. The paper analyzes the range, cost of daily doses of drugs, physical and economic accessibility of HMG-CoA reductase inhibitors. It was determined that the market is import-dependent - the share of domestic drugs is about 35%. The drugs are structured according to the ABC classification, the leading drugs are defined. The economic and physical accessibility of the HMG-CoA reductase inhibitors, which generally indicates their high and medium availability in the pharmaceutical market of Ukraine, was analyzed.

Conclusions: Among the leaders − 9 medicines, only 2 of them - drugs of domestic production, which indicates the possibility of developing a program for the import substitution of this particular group of drugs. Depending on the INN and the manufacturer, the prices of drugs vary within very wide limits, which makes it possible to choose a drug based on its affordability.

Author Biographies

O. M. Ievtushenko, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor, Department of  Pharmaceutical Marketing and Management

V. D. Nemtsova, National Medical University Kharkiv

PhD of Medical Science, Associate Professor, Department of Clinical Pharmacology and Internal diseases

V. V. Tchaikovsky, State Institution “Institute of Gerontology by D.F. Chebotaryov of the NAMS of Ukraine

Doctor of Medicine, Professor of the Department of Palliative and Hospice Medicine NMAPE named after P.L.Shupik, Member of the expert council on palliative medicine and geriatrics of the Ministry of Health of Ukraine


Statystyka aterosklerozu. (n.d.). Available at:

Tkachova, O. V. & Bogatirchuk, L. P. (2016). Suchasni napriamky udoskonalennia farmatsevtychnoho zabezpechennia naselennia na rehionalnomu rivni: materialy naukovoi-praktychnoi konferentsii (10-11. 05. 2016). Ivano-Frankivsk, 35–43.

Nemchenko, A. & Kurilenko, Ju. (2017). Aktualni problemy rozvytku haluzevoi ekonomiky ta lohistyky : materialy V naukovo-praktychnoi konferentsii z mizhnarodnoiu uchastiu (20-21. 04. 2017). Kharkiv, 410–411.

Iakovlieva, L. V., Mishchenko, O. Y., & Adonkina, V. Y. (2015). Calcium channel blockers: the study of the assortment, socio-economic affordability and volumes of consumption in Ukraine. Socìalʹna farmacìâ v ohoronì zdorov’â, 1(1), 18–24.

Dumenko, T. M., Parіj, V. D., Jakovleva, L. V. & Zіmenkovs'kіj, A. B. (2013). Farmakoekonomika v Ukraini: stan ta perspektyvy rozvytku: materialy VI naukovo-praktychnoi konferentsii ( 22. 11. 2013). Kharkiv: NFaU, 180–281.

Kazak, L. І., Doroshenko, A. M., Djachenko, V. Ju., Zahorodnyi, M. I., Replianchuk, N. D. (2015). Racional'naja farmakoterapija, 1 (34). 36–38.

Malay, L. N. (2014). Statins in the treatment and prevention of cardiovascular diseases: repetition of the past and optimism for the future. Rational Pharmacotherapy in Cardiology, 10(5), 513–524.

Bezdіtko, N. V., Mіshhenko, O. Ja. & Chinush І. V. (2014). Klìnìčna farmacìâ, 2, 62–65.

ATC/DDD Index 2016 [ATC/DDD Index 2016]. – Available at:

Guidelines for ATC classification and DDD assignment. 16-th ed. (2012). WHO Collaborating Centre for Drug Statistics Methodology. Oslo.

Baza danih «Ekvalajzer» TOV «Bіznes-Kredit». (n.d.). Available at:

Kompendium: lekarstvennye preparaty. (n.d). Available at:

Derzhavnyi reiestr likarskykh zasobiv Ukrainy. (n.d). Available at: