The study of the assortment, accessibility and consumption of diuretics in Ukraine

Authors

DOI:

https://doi.org/10.24959/cphj.18.1480

Keywords:

A significant consumption of furosemide is due to the presence of evidence of its effectiveness and affordability of drugs for the population.

Abstract

In Ukraine, the number of patients with arterial hypertension is approximately 40% of the adult population of the country. Diuretics are one of the first-line pharmacological groups for treating hypertension.

Аim. To study the assortment, availability and consumption of diuretics in Ukraine within 2014-2017.

Materials and methods. Analysis of the range of drugs was carried out according to the information retrieval system “Pharmstandard” of the company “Morion”, consumption – by the DDD / 1000 inhabitants per day, social and economic accessibility for a monthly course of treatment – by the adequacy indicator of solvency (Ca.s.).

Results. The results obtained have shown that the assortment of diuretic drugs is rather large at the pharmaceutical market and is presented from 107 to 118 TN based on 10 INN. During the study period diuretics were mainly highly available drugs for the population of Ukraine. The most consumed for the monthly course of treatment of patients with arterial hypertension were drugs of loop diuretics – furosemide and torasemide, as well as indapamide referring to thiazide diuretics. Furasemide was the undisputed leader throughout the study period.

Conclusions. A significant consumption of furosemide is due to the presence of evidence of its effectiveness and affordability of drugs for the population.

Author Biographies

O. V. Tkachоva, National University of Pharmacy

Doctor of Pharmacy (Dr. habil.), associate professor of the Department of Pharmacoeconomics

I. V. Kravchenko, National University of Pharmac

5th year student of the specialty “Clinical Pharmacy”

A. M. Semenov, National University of Pharmac

Candidate of Medicine (PhD), associate professor of the Clinical Pharmacology and Clinical Pharmacy Department 

References

Farmacevtychna encyklopediya. (n.d.). Available at: https://www.pharmencyclopedia.com.ua/article/2549/diuretiki

Perederii, V. H., Tkach, S. M. (2010). Osnovy vnutrishnoi medytsyny. (Vols 2-3) pidruchnyk dlia VMNZ IV rivnia akredytatsii. Vinnytsia: Nova Knyha.

Unifikovanyi klinichnyi protokol pervynnoi, ekstrenoi ta vtorynnoi medychnoi dopomohy «Arterialna hipertenziia». (2012). Available at: http://mtd.dec.gov.ua/images/dodatki/384_2012/384_2012ykpmd_ag.pdf

Derzhavna sluzhba statystyky Ukrainy. (n.d.). Available at: www.ukrstat.gov.ua

Shchorichna dopovid pro stan zdorov’ia naselennia, sanitarno-epidemichnu sytuatsiiu ta rezultaty diialnosti systemy okhorony zdorov’ia Ukrainy za 2016 r. (2017). MOZ Ukrainy, DU «UISD MOZ Ukrainy». Kyiv, 516.

Yakovlieva, L. V., Mishchenko, O. Ya., Adonkina, V. Yu. (2017). Farmakoepidemiolohichni doslidzhennia obsiahiv spozhyvannia antyhipertenzyvnykh likarskykh zasobiv v Ukraini: monohrafiia. Kharkiv: NFaU, 108.

Morozov, A. M., Yakovlieva, L. V., Stepanenko, A. V. (2013). Vyvchennia spozhyvannia likarskykh zasobiv za anatomo-terapevtychno-khimichnoiu klasyfikatsiieiu ta vstanovlenymy dobovymy dozamy. Kharkiv: Styl-Izdat, 34.

Buggey, J., Mentz, R. J., Pitt, B., Eisenstein, E. L., Anstrom, K. J., Velazquez, E. J., & O’Connor, C. M. (2015). A reappraisal of loop diuretic choice in heart failure patients. American Heart Journal, 169(3), 323–333. https://doi.org/10.1016/j.ahj.2014.12.009

Gorbunova, M. L., Vlasova, T. V. (2017). RMZh, 4, 252–256.

Musini, V. M., Rezapour, P., Wright, J. M., Bassett, K., & Jauca, C. D. (2015). Blood pressure-lowering efficacy of loop diuretics for primary hypertension. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.cd003825.pub4

Magee, L., & von Dadelszen, P. (2013). Prevention and treatment of postpartum hypertension. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.cd004351.pub3

Published

2018-11-29

Issue

Section

Pharmacoeconomics