The influence of goutweed (aegopodium podagraria l.) Extract and tincture on the behavioural reactions Of mice against the background of caffeine-sodium benzoate
DOI:
https://doi.org/10.24959/cphj.18.1459Keywords:
mice, CNS, goutweed, caffeine, behavioural reactionsAbstract
Considerable attention has been attracted recently to herbal preparations and dietary components containing hydroxycinnamic acids. High quantity of these compounds is present in the preparations of the aerial part of goutweed (Aegopodium podagraria L.) which exhibit moderate psychotropic and favourable metabolic effects.
Aim. To characterize psychotropic effects of goutweed extract and tincture against the background of caffeine-sodium benzoate in mice.
Materials and methods. The experiments were performed on random-bred mice after the course intragastric administration of goutweed extract (100 mg/kg and 1 g/kg) and goutweed tincture (1 and 5 ml/kg). Against the background of caffeine-sodium benzoate at a dose of 10 mg/kg intraperitoneally, the behavioural reactions were determined in the open-field test. Changes in the levels of anxiety and depression were studied in the elevated plus maze test (EPM) and the tail suspension test, respectively, against the background of a high dose of caffeine-sodium benzoate 120 mg/kg intraperitoneally.
Results. In the open field test, goutweed tincture at a dose of 5 ml/kg eliminated the locomotor-stimulating effect of caffeine in mice, the tincture at a dose of 1 ml/kg and the extract in both doses did not influence on it. Goutweed preparations did not suppress the exploratory behaviour in this test and showed neutrality in relation to the emotional and vegetative manifestations or contributed to their decrease. In the EPM test, the extract in both doses and the tincture at a dose of 5 ml/kg reduced anxiety signs against the background of caffeine, the tincture increased the motor activity. In the tail suspension test, caffeine reduced the duration of immobility of mice, the extract at a dose of 100 mg/kg did not change this effect and eliminated it at a dose of 1 g/kg. The tincture in both doses caused a further decrease in the duration of immobility against the background of caffeine.
Conclusions. Goutweed extract and tincture do not cause a negative influence on the CNS when combined with caffeine, being able to reduce depression and anxiety against the background of this psychostimulant.
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