Antacids for children: clinical and pharmaceutical analysis of the pharmaceutical market of Ukraine
DOI:
https://doi.org/10.24959/cphj.18.1454Keywords:
acid-dependent conditions, heartburn, drugs for the treatment of acid-dependent conditions, antacids, children’s ageAbstract
One of the main symptoms of acid-dependent conditions, gastroesophageal reflux disease, peptic duodenal ulcer and functional dyspepsia is heartburn. This condition is characterized by an unpleasant, sometimes painful sensation of burning in the epigastric region and behind the sternum accompanied with a sour taste in the mouth. Heartburn affects the emotional state of a patient and leads to reduction of the quality of his/her life. The symptom of heartburn can bother not only adults but also children; moreover, the physiological inconsistency of the cardiac sphincter, etc., can be added to its provoking factors, in addition to errors in nutrition and the presence of the gastrointestinal tract diseases. The main drugs for stopping heartburn are antacids, as well as medicines containing alginic acid.
Aim. To develop recommendations for introducing changes or additions to the peculiarities of using antacids in children (under 15 years of age) in the “Protocol of the pharmacist. Symptomatic treatment of heartburn”.
Materials and methods. To achieve the goal the clinical and pharmaceutical analysis of antacid medicines registered and marketed in Ukraine was performed.
Results. As a result of the study it has been found that there are 30 antacids and 6 medicines based on alginic acid registered at the Ukrainian market. All medicines belong to the category of over-the-counter drugs and can be used by patients or the patient’s representatives independently. The analysis of the composition of antacid medicines has been performed, and it has been determined that agents based on aluminum compounds prevail, combinations of calcium and magnesium carbonates are 19.4 %.
When studying the indications for medical use it has been found that in the case of heartburn in children only 14 of 36 trade names can be used. In addition, depending on the age, their ranking can be presented by the following sequence: aluminum phosphate, hydrotalcite, combination of aluminum and magnesium hydroxides, alginates (a standard dose).
Conclusions. It has been recommended to make clarifications in the “Protocol of the pharmacist (pharmaceutist). Symptomatic treatment of heartburn” regarding the possibility of using anti-acid drugs in children of different age.
References
Farmatsevtychna entsyklopediia. Available at: http://www.pharmencyclopedia.com.ua/article/799/pechiya
Tkach, S. M. (2015). Zdorovia Ukrainy, 5, 25–27. Available at: http://health–ua.com/multimedia/userfiles/files/2015/Gastro_2_2015/Gastro_2_2015_25–27.pdf
Nakaz MOZ Ukrainy № 283 vid 18.05.2015 r. Pro zatverdzhennia Pereliku likarskykh zasobiv, dozvolenykh dlia zastosuvannia v Ukraini, yaki vidpuskaiutsia bez retseptiv z aptek ta ikh strukturnykh pidrozdiliv. Available at: http://old.moz.gov.ua/ua/portal/dn_20150518_0283.html
Nakaz MOZ № 875 vid 11.10.2013 r. Pro zatverdzhennia protokoliv provizora (farmatsevta) pry vidpusku bezretsepturnykh likarskykh zasobiv. Available at : http://old.moz.gov.ua/ua/portal/dn_20131011_0875.html
Troian, V. V., Katko, V. A. (2014). Gastroezofagealnaia refliuksnaia bolezn u detei. Minsk: Vysheishaia shkola, 176.
Derzhavnyi reiestr likarskykh zasobiv. Available at: http://www.drlz.com.ua
Kompendium. ATS–klassifikatciia. Available at: https://compendium.com.ua/atc/
Derzhavnyi formuliar likarskykh zasobiv Ukrainy. Available at: http://www.dec.gov.ua/index.php/ua/informatsijno–poshukova–sistema–elektronnij–formulyar
Instruktsiia dlia medychnoho zastosuvannia likarskoho zasobu Pepsan. Available at: http://www.drlz.com.ua/ibp/lz_www.nsf/id/7B48B2A22C6053E7C22582130037ABFB/$file/UA35580201_D77A.mh
Kukes, V. G. (2008). Klinicheskaia farmakologiia, 4–e izd.. Moscow: GEOTAR–Media, 554–559.
Instruktsiia dlia medychnoho zastosuvannia likarskoho zasobu Sekrepat forte. Available at: http://www.drlz.com.ua/ibp/lz_www.nsf/id/B8383348A1DE9A1DC225822400469CE9/$file/UA77830101_88F6.mht
Instruktsiia dlia medychnoho zastosuvannia likarskoho zasobu Gaviskon miatna suspenziia. Available at: http://www.drlz.com.ua/ibp/lz_www.nsf/id/826DB3A0BD76BC4EC22581A60037C805/$file/UA68650102_3292.mht
Instruktsiia dlia medychnoho zastosuvannia likarskoho zasobu Fosfaliuhel. Available at: http://www.drlz.com.ua/ibp/lz_www.nsf/id/340AD1E7D743C4E0C2257E7A002E3140/$file/UA43810101_3264.mht
Instruktsiia dlia medychnoho zastosuvannia likarskoho zasobu Gaviskon miatni tabletky. Available at: http://www.drlz.com.ua/ibp/lz_www.nsf/id/8C04908DD4902177C2258123004E5775/$file/UA68650201_CBE1.mht
Instruktsiia dlia medychnoho zastosuvannia likarskoho zasobu Gaviskon podviinoi dii. Available at: http://www.drlz.com.ua/ibp/lz_www.nsf/id/947721DB59B33EAFC2257C37002D5086/$file/UA133530101_637A.mht
Instruktsiia dlia medychnoho zastosuvannia likarskoho zasobu Gaviskon polunychni tabletky. Available at: http://www.drlz.com.ua/ibp/lz_www.nsf/id/A3926BA770BCF410C2257F7C0059E311/$file/UA92100101_D0FB.mht
Instruktsiia dlia medychnoho zastosuvannia likarskoho zasobu Gaviskon forte miatna suspenziia. Available at: http://www.drlz.com.ua/ibp/lz_www.nsf/id/EA321506CE9E3CBAC22581C50044550C/$file/UA68650101_829E.mht
Instruktsiia dlia medychnoho zastosuvannia likarskoho zasobu Rutatsyd. Available at: http://www.drlz.com.ua/ibp/lz_www.nsf/id/516C7225A2AAD4E6C22582240045C2BA/$file/UA66490101_CC6E.mht
Shabalov, N. P. (2014). Spravochnik pediatra, 3–e izd.. Sankt–Petersburg: Piter, 701–702.
Downloads
Published
Issue
Section
License
Copyright (c) 2018 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
