The effect of 2-ethyl-6-methyl-3-hydroxypyridine succinate on the cortisol level in the blood of patients with acute myocardial infarction and cognitive disorders
Keywords:2-ethyl-6-methyl-3-hydroxypyridine succinate, quercetine, acute myocardial infarction, cortisol
Annually about 50 thousand cases of acute myocardial infarction (AMI) are recorded in Ukraine. One of the causes leading to unfavorable course of AMI is cognitive disorders, which are beyond the age limit in half of the cases.
Aim. To study the effect of 2-ethyl-6-methyl-3-hydroxypyridine succinate on the cortisol level in the blood of patients with AMI and cognitive disorders.
Materials and methods. The study included 70 patients with AMI and cognitive dysfunction under 60 years old. Additionally, the cortisol levels in the blood serum were studied. Depending on the type of treatment the patients were divided into 2 groups: Group 1 (n=35) – patients with the standard treatment scheme in case of AMI and quercetine, Group 2 (n=35) – patients together with the standard treatment and quercetine received 2-ethyl-6-methyl-3-hydroxypyridine succinate.
Results. The study showed that in Group 1 cortisol was increased in 86 % of patients, while in Group 2 it was increased in 80 %. On the background of the treatment provided in Group 1 the cortisol levels were elevated in 45.70 % of patients, while in Group 2 the increase was in 22.85 % of patients. It was found that 2-ethyl-6-methyl-3-hydroxypyridine succinate added to the standard treatment scheme gave a significant decrease of the cortisol levels in the blood of patients in Group 2, whereas in patients receiving the standard therapy and quercetine the regression of the blood serum cortisol was significantly lower.
Conclusions. The study has made it possible to prove that 2-ethyl-6-methyl-3-hydroxypyridine succinate used along with the standard treatment leads to significant decrease of the cortisol levels in the blood serum and cognitive disorders in patients with AMI under 60 years old.
World Health Organization: WHO. Available at : http://www.who.int/en/
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R. (2017). Heart Disease and Stroke Statistics – 2017 Update: A Report From the American Heart Association. Circulation, 135 (10), e146–e603. doi: 10.1161/cir.0000000000000491
Kozhukhov, S. N. (2017). Sertseva nedostatnist ta komorbidni stany, 1, 39–45.
Hadziuk V. A. (2014). Ukrainskyi kardiolohichnyi zhurnal, 3, 45–52.
Nichols, M., Townsend, N., Scarborough, P., Rayner, M. (2012). Evropean cardiovascular disease statistics 2012 edition, 1–125.
Dowdy, D. W., Eid, M. P., Sedrakyan, A., Mendez–Tellez, P. A., Pronovost, P. J., Herridge, M. S., Needham, D. M. (2005). Quality of life in adult survivors of critical illness: A systematic review of the literature. Intensive Care Medicine, 31 (5), 611–620. doi: 10.1007/s00134–005–2592–6
Jutla, S. K., Yuyun, M. F., Quinn, P. A., Ng, L. L. (2014). Plasma cortisol and prognosis of patients with acute myocardial infarction. Journal of Cardiovascular Medicine, 15 (1), 33–41. doi: 10.2459/jcm.0b013e328364100b
De Rooij, S. R. (2013). Blunted cardiovascular and cortisol reactivity to acute psychological stress: A summary of results from the Dutch Famine Birth Cohort Study. International Journal of Psychophysiology, 90 (1), 21–27. doi: 10.1016/j.ijpsycho.2012.09.011
Copyright (c) 2018 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).