The methodology of developing dermato-cosmetic remedies for prevention and treatment of alopecia

M. I. Fedorovska, N. P. Polovko, I. O. Yarema


Prevention and treatment of alopecia remains an important task of modern dermatology and cosmetology. There are different types of baldness depending on the etiology and pathogenetic factors, among them androgenic alopecia (AA)
and telogen effluvium (TE) are the most common.
Aim. To substantiate the methodology of developing new dermatological remedies intended for the cutaneous application in prevention and treatment of AA and TA.
Materials and methods. The study was conducted by processing the research literature in etiology, pathogenesis and applied therapeutic methods of various types of alopecia, marketing analysis of drugs and cosmetics, the search of the
medicinal plant raw material, determination of the effect of biologically active substances on recovery and the hair follicle growth stimulation.
Results. Taking into account the specificity of pharmacotherapy of alopecia and the marketing research data the study objects were selected, namely for AA treatment – soft dosage forms (emulsion gel, cream-mask, gel-mask) with Saw Palmetto fruits extract and Sophora japonica tincture, an oil extract from nettle rhizomes and roots; for TA treatment – a gel-mask with nettle juice, a complex tincture of nettle leaves, sage leaves and horse chestnut leaves. In order to provide stability, high efficiency and safety it is important to take into account the impact of pharmaceutical factors on the quality of drugs to be developed using modern research methods (pharmacotechnological, biopharmaceutical, physicochemical, pharmacological) and the sequence of their performance.
Conclusions. Thus, based on the general methodological approach the algorithm for developing dermato-cosmetic remedies with the natural raw material has been worked out, in future these remedies can be the medicines of choice in prevention and treatment of AA and TA.


alopecia; dermato-cosmetic remedies; methodology; technology


Kardashova, D. Z., Vasilenko, I. A., Karasev, E. A. (2012). Eksperimentalnaia i klinicheskaia dermatokosmetologiia, 1, 58–63.

Solnoshenko, E .N. (2009). Mezhdunarodnyi meditcinskii zhurnal – International medical journal, 1, 102–109.

Galliamova, Yu. A. (2012). Lechashchii vrach, 10, 14–17.

Serbina, I. M. (2016). Mizhnarodnyi medychnyi zhurnal – International medical journal, 4, 77–82.

Yip, L., Rufaut, N., Sinclair, R. (2011). Role of genetics and sex steroid hormones in male androgenetic alopecia and female pattern hair loss: An update of what we now know. Australasian Journal of Dermatology, 52 (2), 81–88. doi: 10.1111/j.1440– 0960.2011.00745.x

Fedorovska, M. I. (2014). Fitoterapiia. Chasopys, 2, 40–44.

Kaushik, R., Gupta, D., Yadav, R. (2011). Alopecia: herbal remedies. Intern. Journal of Pharmaceutical Science and Research, 2 (7), 1631–1637.

Сhatterjee, S., Agrawala, S .K. (2003). Saw palmetto (Serenoa repens) in androgenic alopecia. Natural Product Radiance, 2 (6), 302–305.

Demchuk, M. B., Ivashkiv, Yu. I., Hroshovyi, T. A. (2012). Zaporozhskii meditcinskii zhurnal – Zaporozhye Medical Journal, 3 (72), 23–25.

Derzhavnyi reiestr likarskykh zasobiv. Available at:

GOST Style Citations

1. Кардашова, Д. З. Комплексный подход – основа эффективного лечения алопеции / Д. З. Кардашова, И. А. Василенко, Е. А. Карасев // Экспериментальная и клиническая дерматокосметол. – 2012. – № 1. – С. 58–63.

2. Солошенко, Э. Н. Клинические разновидности алопеций : патогенез, дифференциальная диагностика, терапия / Э. Н. Солошенко // Междунар. мед. журн. – 2009. – № 1. – С. 102–109.

3. Галлямова, Ю. А. Стратегия и тактика лечения диффузного поредения волос / Ю. А. Галлямова // Лечащий врач. – 2012. – № 10. – С. 14–17.

4. Сербина, И. М. Патогенез гнездной алопеции: иммунные механизмы / И. М. Сербина // Міжнар. мед. журн. – 2016. – № 4. – С.77–82.

5. Yip, L. Role of genetics and sex steroid hormones in male androgenetic alopecia and female pattern hair loss : An update of what we now know / L. Yip, N. Rufaut, R. Sinclair // Australasian J. of Dermatol. – 2011. – Vol. 52, Issue 2. – P. 81–88. doi: 10.1111/j.1440–0960.2011.00745.x

6. Федоровська, М. І. Перспективи застосування лікарських рослин при різних формах алопеції / М. І. Федоровська // Фітотерапія. Часопис. – 2014. – № 2. – С. 40–44.

7. Kaushik, R. Alopecia : herbal remedies / R. Kaushik, D. Gupta, R. Yadav // Intern. J.l of Pharm. Sci. and Res. – 2011. – Vol. 2, Issue 7. – P. 1631–1637.

8. Сhatterjee, S. Saw palmetto (Serenoa repens) in androgenic alopecia / S. Сhatterjee, S. K. Agrawala // Natural Product Radiance. – 2003. – Vol. 2, Issue 6. – P. 302–305.

9. Демчук, М. Б. Дослідження вітчизняного ринку лікарських препаратів і засобів лікувальної косметики, що використовуються при зовнішній корекції алопеції / М. Б. Демчук, Ю. І. Івашків, Т. А. Грошовий // Запорожский мед. журн. – 2012. – № 3 (72). – С. 23–25.

10. Державний реєстр лікарських засобів. – Режим доступу :

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Abbreviated key title: Klìn. farm.

ISSN 2518-1572 (Online), ISSN 1562-725X (Print)