DOI: https://doi.org/10.24959/cphj.18.1442

Clinical and laboratory indicators for infectious mononucleosis in children on the background of the treatment with valavir

Ya. V. Kolesnik

Abstract


Infectious mononucleosis (IM) is an acute infectious disease accompanied with fever, quinsy, damage of lymph nodes, liver, spleen and characteristic changes in the hemogram. The global spread of IM among the population, frequency of its chronic course, the presence of erased and atypical forms, the complexity of diagnosis and therapy cause the urgency of the problem of studying IM.
Aim. To compare clinical and laboratory indicators in the acute period of IM in children treated with valavir.                                                                          Materials and methods. The article contains the results of the own observations of 107 children with IM aged 2 to 15 years. Clinical and laboratory data were evaluated in patients with IM on the background of the treatment with valavir. Results. The main therapy was antihistamines and symptomatic drugs, antimicrobials were prescribed for the treatment of quinsy. Valavir was prescribed on the first day of admission with clinical verification of the diagnosis. Verification of pathogens was carried out by the method of enzyme immunoassay, specific immunoglobulins M and G were determined separately for VEB antigens by the PCR method. The disease in all children was accompanied with fever, tonsillitis, lymphadenopathy, enlargement of the liver and spleen. The study of clinical and laboratory features was conducted at the time of admission to the hospital and on the 12th day of hospitalization.        Conclusions. According to the results of the study the conclusions have been made that prescription of valavir in the treatment of acute infectious mononucleosis in children leads to a more rapid disappearance of a number of clinical symptoms and normalization of laboratory indicators compared to patients who received only the symptomatic and pathogenetic therapy.


Keywords


infectious mononucleosis; acyclic nucleoside analogs; treatment; clinical indicators

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References


Gorokhova, L. A., Saraeva, N. O. (2000). Sibirskii meditcinskii zhurnal, 3, 14–17.

Tiuniaeva, N. O., Sofronova L. V. (2014). Vestnik novykh meditcinskikh tekhnologii – Journal of New Medical Technologies, 3, 184–190.

Kazmirchuk, V. E., Maltcev, D. V. (2011). Klinicheskaia immunologiia. Allergologiia. Infektologiia, 5 (91), 69–75.

Kramarev, S. A., Vygovskaia, O. V. (2013). Aktualnaia infektologiia – Actual Infectology, 1 (1), 73–78.

Vygovskaia, O. V., Kramarev, S. A., Doroshenko, V. O., Shpak, I. V. (2012). Praktykuiuchyi likar, 4, 29–34.


GOST Style Citations


1. Горохова, Л. А. Инфекционный мононуклеоз / Л. А. Горохова, Н. О. Сараева // Сибирский мед. журн. – 2000. – № 3. – С. 14–17.

2. Тюняева, Н. О. Инфекционный мононуклеоз : этиологические факторы, проблемы диагностики и лечения / Н. О. Тюняева, Л. В. Софронова // Вестник новых мед. технол. – 2014. – № 3. – С. 184–190.

3. Казмирчук, В. Е. Диагностика и лечение инфекции, вызванной Эпштейна–Барра вирусом (вирусом герпеса человека 4 типа) / В. Е. Казмирчук, Д. В. Мальцев // Клиническая иммунол. Аллергол. Инфектол. – 2011. – № 5 (91). – С. 69–75.

4. Крамарев, С. А. Эпштейна – Барра вирусная инфекция у детей / С. А. Крамарев, О. В. Выговская // Актуальная инфектол. – 2013. – № 1 (1). – С. 73–78.

5. Инфекционный мононуклеоз Эпштейна-Барра вирусной этиологии у детей : вопросы этиологии, патогенеза, иммуногенеза, лечения / О. В. Выговская, С. А. Крамарев, В. О. Дорошенко, И. В. Шпак // Практикуючий лікар. – 2012. – № 4. – С. 29–34.





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Abbreviated key title: Klìn. farm.

ISSN 2518-1572 (Online), ISSN 1562-725X (Print)