The study of the effect of the combination of quercetin and glucosamine derivatives on the course of the membranous kidney damage in the experiment
DOI:
https://doi.org/10.24959/cphj.17.1445Keywords:
quercetin, glucosamine hydrochloride, N-acetylglucosamine, doxorubicin nephropathyAbstract
The search for effective and affordable drugs for the treatment of chronic kidney disease (CKD) is an important problem in modern medicine. Development of CKD leads to imminent renal failure, disability of patients and the loss of social activity. Today most patients with CKD do not have the opportunity to receive the specialized medical care in Ukraine.
Aim. To study experimentally the effect of the combination of quercetin and glucosamine derivatives on the course of the membranous kidney damage in rats.
Materials and methods. The studies were performed on the model of doxorubicin nephropathy in 60 rats. In animals the urine was studied; the kidney mass ratio, the glomerular filtration rate and the urea blood level were determined.
Results. In the course of the study it was shown that under the effect of the combination of quercetin and glucosamine derivatives studied there was a significant decrease of the level of proteinuria, the kidney mass ratio, blood urea and an increase of the GFR index. It indicates normalization of the functional state of the kidneys. At the same time, by the degree of its effect the combination was superior to the activity of the reference drugs – quercetin and lespefril.
Conclusions. The combination of quercetin with glucosamine derivatives studied under the conditions of the doxorubicin nephropathy development in rats has a pronounced nephroprotective effect and is a promising drug for correction of chronic kidney disease.
References
Kolesnyk, M. O., Saidakova, N. O., Kozliuk, N. I. et al. (2017). Ukrainskyi zhurnal nefrolohii ta dializu, 1 (53), 3–12.
Pyrih, L. A., Ivanov, D. D. (2014). Nefrolohiia.Donetsk: Vydavets Zaslavskyi, 292.
Skvortsov, V. V., Tumarenko, A. V. (2017). Klinicheskaia nefrologiia. Sankt–Peterburg: SpetsLit, 199.
Shebeko, S. K., Zupanets, I. A. (2006). Klinichna farmatsiia – Clinical Pharmacy, 10 (2), 31–35.
Zupanets, I.A., Shebeko, S. K. (2007). Medychna khimiia, 9 (1), 67–71.
Zupanets, I. A., Shebeko, S. K., Kharchenko, D. S. (2009). Visnyk farmatsii – News of Pharmacy, 2, 75–78.
Kharchenko, D. S. (2009). The research of quercetin parenteral form influence on the course of experimental glomerulonephritis. Drug Information Journal, 2 (43), 228–229.
Shebeko, S. K. (2017). Ukrainskyi biofarmatsevtychnyi zhurnal – Ukrainian biopharmaceutical journal, 5, 40–44.
9. Guide for the care and use of laboratory animals, 8th edition. (2011).Washington: The National Academies Press, 246.
10. European convention for the protection of vertebrate animals used for experimental and other scientific purpose: Council of Europe (1986).Strasbourg, 52.
Shtryhol, S. Yu., Lisovyi V. M., ZupanetsI.A. et al. (2009). Metody eksperymentalnoho modeliuvannia urazhennia nyrok dlia farmakolohichnykh doslidzhen. Kharkiv: NUPh, 48.
Zupanets, К. O., Popov S. B., Otrishko, I.A. (2009). Klinichna farmatsiia –Clinical Pharmacy, 13 (4), 50–53.
El Aarazh, A., Zupanets, I. A., Shebeko, S. K., Otrishko, I.A. (2012). Klinichna farmatsiia – Clinical Pharmacy, 16 (3), 24–27.
Stefanov, A. V. (2002). Doklinicheskie issledovaniia lekarstvennykh sredstv.Kiev: Avitcenna, 528.
Dolgov, V. V., Menshikov V. V. (2012). Klinicheskaia laboratornaia diagnostika.Moscow: GEOTAR–Media, 928.
Kamyshnikov, V. S. (2011). Metody klinicheskikh laboratornykh issledovanii.Moscow: MEDpress–inform, 752.
Trukhacheva, N. V. (2012). Matematicheskaia statistika v mediko–biologicheskikh issledovaniiakh s primeneniem paketa Statistica.Moscow: GEOTAR–Media, 379.
Downloads
Published
Issue
Section
License
Copyright (c) 2017 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
