The effect of vaginal pessaries on iron hemostasis against the background of the experimental positive Escherichia coli vaginitis

O. V. Dolzhykova, L. M. Maloshtan, R. F. Yeriomenko

Abstract


Currently, disorders of the vaginal flora are observed in 38 % of women, 11 % of them have aerobic vaginitis. Streptococcus agalactiae and Escherichia coli, which capture iron of the human body during bacterial infections, are isolated most frequently in cases of vaginitis.

Aim. To study the effect of vaginal pessaries “Klimedeks” and “Melanizol” on iron hemostasis in female rats against the experimental positive Escherichia coli vaginitis.

Materials and methods. The experiment was conducted on non-linear mature female rats modeled with positive Escherichia coli vaginitis. The parameters of the course of vaginitis were the pH values of the vaginal secretion, the level of iron and the iron binding ability of the blood serum.

Results. The experimental vaginitis was manifested by hyperemia of the vaginal mucosa accompanied with yellow secretions, a significant increase in pH, a decrease in the iron level and the iron binding capacity by 17.4 % and 15.1 %, respectively. Under the effect of the pessaries “Melanizol” and “Klimedeks” studied the pH level decreased, while the level of iron (by 26 % and 30 %, respectively) and the iron-binding capacity (by 12.5 % and 13 %, respectively) increased; the effectiveness of pessaries studied was at the level of the reference drug – vaginal tablets “Micogynax” and exceeded the effect of the reference suppositories “Gravagin”. But the pessaries “Melanizol” was less efficient than “Klimedeks”.

Conclusions. Thus, the pessaries “Klimedeks” and “Melanizol” studied have the therapeutic effect against the background of positive Escherichia coli vaginitis, affect on iron hemostasis, and can be recommended for further study as drugs for the treatment of vaginitis with mixed infection.


Keywords


experimental vaginitis; rats; Escherichia coli; iron; iron-binding ability

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DOI: https://doi.org/10.24959/cphj.17.1437

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