The effect of the composition containing the combination of doxycycline hydrochloride and glucosamine hydrochloride on the immunosorbent indicators in rats with collagen-induced arthritis

K. M. Tkachenko, I. A. Otrishko, S. K. Shebeko

Abstract


On the model of collagen-induced arthritis in rats the anti-inflammatory properties of the composition containing the combination of doxycycline hydrochloride and glucosamine hydrochloride have been studied in comparison with its active monocomponents – doxycycline, glucosamine hydrochloride. According to the results of the experimental studies conducted it has been proven that the composition containing the combination of doxycycline hydrochloride and glucosamine hydrochloride has a strong beneficial effect on the metabolism of the cartilage and bone tissue on the background of the autoimmune arthritis development and leads to inhibition of autoimmune processes in the connective tissue of animals. The normalization of the functional state of the joints and the immunosorbent indicators has been observed. According to the degree of pharmacological effects on the most parameters studied the combination exceeds the reference objects – the substance of doxycycline hydrochloride and glucosamine hydrochloride. The composition containing the combination of doxycycline hydrochloride and glucosamine hydrochloride is a promising corrector of the inflammatory and destructive joint diseases with the autoimmune component, and can be recommended for application in the complex therapy of patients with immuno-inflammatory and inflammatory-destructive diseases of the joints.

Keywords


doxycycline hydrochloride; glucosamine hydrochloride; combination; collagen-induced arthritis; eicosanoids

References


Балабанова Р.М. // Совpeменная ревматол. – 2014. – №2. – С. 92-95.

Зупанець І.А., Ткаченко К.М., Отрішко І.А., Грінцов Є.Ф. // Укр. журн. клінічної та лабораторної медицини. – 2014. – Т. 9, №3. – С. 37-40.

Зупанец И.А., Ткаченко Е.М., Сахарова Т.С. // Эксперимент. и клин. фармакол. – 2012. – №12. – С. 49-50.

Камышников В.С. Лабораторная диагностика внутренних и хирургических болезней: Учеб. пособие. – Мн: Адукацыя і выхаванне, 2012. – 584 с.

Каратеев А.Е., Успенский Ю.П., Пахомова И.Г., Насонов Е.Л. // Научно-практ. ревматол. – 2012. – №3. – С. 101-133.

Лапач С.Н., Чубенко А.В., Бабич П.Н. Статистические методы в медико-биологических исследованиях с использованием Excel. – 2-е изд. – К.: Морион, 2001. – 407 с.

Настанова СТ-Н МОЗУ 42-6.0:2008. Лікарські засоби. Належна лабораторна практика (видання офіційне) / О.Стефанов, Т.Бухтіарова, В.Коваленко та ін. – К.: Моріон, 2009. – С. 37-68.

Остеоартроз: консервативная терапия: Монография / Под ред. Н.А.Коржа, Н.В.Дедух, И.А.Зупанца. – Х.: Золотые страницы, 2007. – 424 с.

Руководство по проведению доклинических исследований лекарственных средств. Ч. І / Под ред. А.Н.Миронова. – М.: Гриф и К, 2012. – 944 с.

Чичасова Н.В. // Лечащий врач. – 2007. – №2. – С. 22-26.

Altman R.D. // Expert Rev. Clinical Pharmacol. – 2009. – Vol. 2 (4). – P. 359-371.

O’Dell J.R., Elliott J.R., Mallek J.A. // Arthritis & Rheumatism. – 2006. – Vol. 2. – Р. 621-627.

Remmers E.F., Joe B., Griffiths M.M. et al. // Arthritis & Rheumatism. – 2002. Vol. 46, №8. – P. 2225-2234.


GOST Style Citations






DOI: https://doi.org/10.24959/cphj.16.1399

Abbreviated key title: Klìn. farm.

ISSN 2518-1572 (Online), ISSN 1562-725X (Print)