The study of effects of “Chondrolife” combined cream-gel in the spontaneous pain sensitivity experiment

S. K. Shebeko, S. M. Zimin


The leading areas of pathogenetic treatment of osteoarthritis include: modulation of inflammation, regulation of metabolism and stimulation of chondrocytes of cartilage synthesis. [6] Reduction of pain - another no less important aspect of treatment [7]. Today, along with the regular use of drugs in the treatment of articular syndrome in osteoarthritis focuses on local therapy, including the use of ointments and gels. [15] The aim of this study was to study the analgesic action of the original cream-gel codenamed "Chondrolife" containing glucosamine hydrochloride, chondroitin sulfate, camphor and menthol. Antinociceptive effect of cream gel "Chondrolife" compared to reference drugs "Chondroxide®" gel and "Fastum gel" studied at cutaneous application on the model karahenin-induced acute gonarthritis in rats by impact to the severity of spontaneous pain using an Incapacitance Tester MkV („Linton Instrumentation”, Great Britain). Cream-gel "Chondrolife " showed significantly better antinociceptive effect compared to the reference drug "Chondroxide®" gel and not inferior antinociceptive activity "Fastum gel" on the 6th hour (in 1 hour after drugs application) and, although the seventh hour activity (in 2 hours after drugs application) of cream-gel " Chondrolife " gradually reduced and slightly inferior activity "Fastum gel", it is likely higher than the gel " Chondroxide®" that gives reason to continue study of combined cream-gel " Chondrolife" as chondroprotective analgesic agent and local use.


osteoarthritis; glucosamine; chondroitine; topical drugs; pain; analgesimetry

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Балабанова Р. М. Динамика распространенности ревматических заболеваний, входящих в XIII класс МКБ-10, в популяции взрослого населения Российской Федерации за 2000–2010 гг. / Р.М. Балабанова, Ш. Ф. Эрдес // Научно-практическая ревматология. – 2012. – № 3. – С. 10–12.

Доклинические исследования лекарственных средств : метод. рек. / под ред. А.В. Стефанова. – К: Авиценна, 2002. – 528 с.

Зупанец И.А., Зимин С.М. Анализ эффективности оригинального комбинированного хондропротектора на модели системного стероидного артроза у крыс/ European Applied Sciences. - 2013, 10 (1). - Р. 58-61.

Науково-практичні рекомендації з утримання лабораторних тварин та роботи з ними / Ю. М. Кожем’якін, О. С. Хромов, М. А. Філоненко, Г. А. Сайфетдінова. – К.: Державний фармакологічний центр МОЗ України, 2002. – 155 с.

An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: a report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) / O. Bruyère, C. Cooper, J. P. Pelletier [et al.] // Semin. Arthritis Rheum. – 2014. – Vol. 44, № 3. – P. 253-263.

EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis / W. Zhang, M. Doherty, G. Peat [et al.] // Ann. Rheum. Dis. – 2010. – Vol. 69, № 3. – P. 483–489.

EULAR Textbook on Rheumatic Diseases / Editor Johannes W. J. Bijlsma // Osteoarthritis treatment. – 2012. – P. 749–768.

European convention for the protection of vertebrate animals used for experimental and other scientific purpose : Council of Europe. – Strasbourg, 1986. – 52 p.

Harirforoosh S. Adverse Effects of Nonsteroidal Antiinflammatory Drugs: An Update of Gastrointestinal, Cardiovascular and Renal Complications / S. Harirforoosh, W. Asghar, F. Jamali // J. Pharm. Sci. – 2013. – Vol. 16, № 5. – P. 821–847.

Hrnack S. A. Managing the pain of knee osteoarthritis / S. A. Hrnack, F. A. Barber // Phys. Sportsmed. – 2015. – Vol. 42, № 3. – P. 63-70.

MOST and OAI investigators. Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI // D. T. Felson, J. Niu, T. Yang [et al.] // Osteoarthritis Cartilage. – 2013. – Vol. 21, № 6. – P. 789–795.

New findings in osteoarthritis pathogenesis: therapeutic implications // L. Pulsatelli, O. Addimanda, V. Brusi [et al.] // Ther. Adv. Chronic Dis. – 2013. – Vol. 10, № 1. – P. 23-43.

OARSI guidelines for the non-surgical management of knee osteoarthritis / T. E. McAlindon, R. R. Bannuru, M. C. Sullivan [et al.] // Osteoarthritis and Cartilage. – 2014. – Vol. 22, № 3. – P. 363–388.

Peniston J. H. An open–label, long–term safety and tolerability trial of diclofenac sodium 1% gel in patients with knee osteoarthritis / J. H. Peniston, M. S. Gold, L. K. Alwine // Phys. Sportsmed. – 2011. – Vol. 39, № 3. – P. 31–38.

Prevention of Knee Osteoarthritis in Overweight Females: The First Preventive Randomized Controlled Trial in Osteoarthritis / J. Runhaar, M. van Middelkoop, M. Reijman [et al.] // Am. J. Med. – 2015. – Vol. 128, № 8. – P. 888-895.

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