The study of effects of “Chondrolife” combined cream-gel in the spontaneous pain sensitivity experiment

S. K. Shebeko, S. M. Zimin

Abstract


The leading areas of pathogenetic treatment of osteoarthritis include: modulation of inflammation, regulation of metabolism and stimulation of chondrocytes of cartilage synthesis. [6] Reduction of pain - another no less important aspect of treatment [7]. Today, along with the regular use of drugs in the treatment of articular syndrome in osteoarthritis focuses on local therapy, including the use of ointments and gels. [15] The aim of this study was to study the analgesic action of the original cream-gel codenamed "Chondrolife" containing glucosamine hydrochloride, chondroitin sulfate, camphor and menthol. Antinociceptive effect of cream gel "Chondrolife" compared to reference drugs "Chondroxide®" gel and "Fastum gel" studied at cutaneous application on the model karahenin-induced acute gonarthritis in rats by impact to the severity of spontaneous pain using an Incapacitance Tester MkV („Linton Instrumentation”, Great Britain). Cream-gel "Chondrolife " showed significantly better antinociceptive effect compared to the reference drug "Chondroxide®" gel and not inferior antinociceptive activity "Fastum gel" on the 6th hour (in 1 hour after drugs application) and, although the seventh hour activity (in 2 hours after drugs application) of cream-gel " Chondrolife " gradually reduced and slightly inferior activity "Fastum gel", it is likely higher than the gel " Chondroxide®" that gives reason to continue study of combined cream-gel " Chondrolife" as chondroprotective analgesic agent and local use.

Keywords


osteoarthritis; glucosamine; chondroitine; topical drugs; pain; analgesimetry

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References


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DOI: https://doi.org/10.24959/cphj.16.1394

Abbreviated key title: Klìn. farm.

ISSN 2518-1572 (Online), ISSN 1562-725X (Print)