The quality analysis of pharmacotherapy of patients with sciatica

L. V. Iakovlieva, O. Ya. Mishchenko, I. V. Konuschynska


The article presents the results of the rationality assessment for pharmacotherapy of patients with sciatica on the basis of pooled VEN/ frequency analysis. A retrospective analysis of medication administration records of 112 patients diagnosed with sciatica has been conducted. A total of 61 TNs (46INN) were prescribed to patients with sciatica. The total number of prescriptions was 964, the number of prescriptions per a patient – 8.6, indicating polypharmacy. The main directions of pharmacotherapy of patients with sciatica have been determined. They are anti-inflammatory and analgesic (non-opioid analgesics, NSAIDs, local anesthetics), antispasmodic (muscle relaxants), perfusion therapy to improve microcirculation and hemodynamics; they comply with the requirements of the current regulations – Clinical Protocol of medical care for patients with dorsalgia (2007). Comparison of the results of VEN and frequency analysis indicates that there are non-essential drugs with the metabolic action in the doctor’s prescriptions, such as deproteinized blood derivative (actovegin), L-lysine aescinat, etc. In case of prescribing a significant number of non-essential drugs with the metabolic action leading to polypharmacy the use of antisecretory drugs, in particular proton pump inhibitors, to prevent complications in the gastrointestinal tract, which may be caused by NSAIDs, is insufficient. A possible way to increase the rationality of pharmacotherapy of patients with sciatica is to reduce the number of prescriptions of non-essential drugs that will reduce the number of prescriptions to a patient.


back pain; sciatica; pharmacotherapy; retrospective analysis of drug prescriptions; VEN analysis; frequency analysis

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