Human pharmacogenetic pecularities affecting the action of anti-tuberculosis medicines
DOI:
https://doi.org/10.24959/cphj.16.1374Keywords:
genetic polymorphism, tuberculosis, CYP, NAT2Abstract
For a long time it is known about deviations in efficiency and toxicity of the medications in different persons. These could be related to genetic polymorphism of the person, which determine metabolism of medications. In this connection, studying of genes polymorphism, which controls the processes of medicines biotransformation in human, and its influence on the effectiveness and safety of treatment of different diseases, including tuberculosis (TB) is an important task of clinical pharmacology. In given review there are data related to the value of genotype polymorphisms, which determine activity of two cytochromes (CYP) 450 – CYP2E1 and CYP2C9, and also N-acetyltransferase-2 (NAT2), for concentration in blood of the most effective anti-tuberculosis preparations isoniazid and rifampicin, for efficiency and toxicity of TB treatment. It is shown that polymorphism of CYP2C9, CYP2E1, NAT2, GST, UGT genotype in TB patients can be used as predictors of antitubercular drug-induced liver injuries. Variation of human genes that control transcription of interleukins, interferon-γ, SLC11A1 etc predicts TB susceptibility and treatment outcome.
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