Peculiarities of the circadian dynamics of the carbohydrates metabolism and cytolisis markers in rats

Authors

  • K. O. Kalko National University of Pharmacy, Ukraine
  • O. Ya. Mishchenko National University of Pharmacy, Ukraine
  • A. V. Kononenko National University of Pharmacy, Ukraine
  • T. V. Gorbach Kharkiv National Medical University, Ukraine
  • T. K. Yudkevych National University of Pharmacy, Ukraine
  • S. M. Drogovoz National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/cphj.16.1371

Keywords:

liver, circadian rhythm, carbohydrates, marker cytolysis

Abstract

The aim of the study was to determine the circadian dynamics of the carbohydrate metabolism and the activity of cytolysis markers in females and male rats. For this purpose the chronopharmacological studies with collecting blood and liver tissues of the experimental rats at the scheduled time (03.00, 09.00, 15.00 and 21.00) have been carried out. As a result of the research conducted the presence of diurnal fluctuations in the glycogen level, the content of corticosterone and glucose in male rats with the lower rhythm expression in females, and the practical absence of the circadian rhythm in the activity of ALT and AST in animals of both sexes have been determined. Significant gender differences between male and female rats have not been revealed. The results of the circadiance organization of the carbohydrate metabolism and the activity of cytolysis markers obtained in rats should be taken into account when analyzing a chronoprofile of hepatoprotectors and other drugs.

References

Біохімія: Підруч. / За заг. ред. проф. А.Л.Загайка, проф. К.В.Александрової. – Х.: Вид-во «Форт», 2014. – 728 с. 2.

Доклінічні дослідження лікарських засобів: Метод. рекоменд. / За ред. чл.-кор. НАМН України О.В.Стефанова. – К.: Авіценна, 2001. – 528 с.

Дроговоз С.М. Хронофармакология наглядно (Хронофармакология в таблицах и рисунках): Справочник – учебное пособие. – Х.: Титул, 2014. – 128 с.

Камышников В.С. Справочник по клинико-биохимической лабораторной диагностике: в 2-х т. – Мн: Беларусь, 2000. – Т. 1. – 495 с.

Парахонский А.П. // Успехи современного естествознания. – 2006. – №12. – С. 68-69.

Реброва О. Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. – 3-е изд. – М.: МедиаСфера, 2006. – 312 с.

Семененко С.Б. // Буковинський мед. вісник. – 2014. – Т. 18, №2 (70). – С. 99-101.

Хильдебрандт Г., Мозер М., Лехофер М. Хронобиология и хрономедицина. – М.: Арнебия, 2006. – 144 с.

Tong X. // Compr. Physiol. – 2013. – №3. – Р. 917-940.

Downloads

Published

2016-09-02

Issue

Vol. 20 No. 3 (2016)

Section

Pre-clinical studies of new drugs

License

Copyright (c) 2016 National University of Pharmacy

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).