Peculiarities of the circadian dynamics of the carbohydrates metabolism and cytolisis markers in rats

K. O. Kalko, O. Ya. Mishchenko, A. V. Kononenko, T. V. Gorbach, T. K. Yudkevych, S. M. Drogovoz


The aim of the study was to determine the circadian dynamics of the carbohydrate metabolism and the activity of cytolysis markers in females and male rats. For this purpose the chronopharmacological studies with collecting blood and liver tissues of the experimental rats at the scheduled time (03.00, 09.00, 15.00 and 21.00) have been carried out. As a result of the research conducted the presence of diurnal fluctuations in the glycogen level, the content of corticosterone and glucose in male rats with the lower rhythm expression in females, and the practical absence of the circadian rhythm in the activity of ALT and AST in animals of both sexes have been determined. Significant gender differences between male and female rats have not been revealed. The results of the circadiance organization of the carbohydrate metabolism and the activity of cytolysis markers obtained in rats should be taken into account when analyzing a chronoprofile of hepatoprotectors and other drugs.


liver; circadian rhythm; carbohydrates; marker cytolysis


Біохімія: Підруч. / За заг. ред. проф. А.Л.Загайка, проф. К.В.Александрової. – Х.: Вид-во «Форт», 2014. – 728 с. 2.

Доклінічні дослідження лікарських засобів: Метод. рекоменд. / За ред. чл.-кор. НАМН України О.В.Стефанова. – К.: Авіценна, 2001. – 528 с.

Дроговоз С.М. Хронофармакология наглядно (Хронофармакология в таблицах и рисунках): Справочник – учебное пособие. – Х.: Титул, 2014. – 128 с.

Камышников В.С. Справочник по клинико-биохимической лабораторной диагностике: в 2-х т. – Мн: Беларусь, 2000. – Т. 1. – 495 с.

Парахонский А.П. // Успехи современного естествознания. – 2006. – №12. – С. 68-69.

Реброва О. Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. – 3-е изд. – М.: МедиаСфера, 2006. – 312 с.

Семененко С.Б. // Буковинський мед. вісник. – 2014. – Т. 18, №2 (70). – С. 99-101.

Хильдебрандт Г., Мозер М., Лехофер М. Хронобиология и хрономедицина. – М.: Арнебия, 2006. – 144 с.

Tong X. // Compr. Physiol. – 2013. – №3. – Р. 917-940.

GOST Style Citations

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Abbreviated key title: Klìn. farm.

ISSN 2518-1572 (Online), ISSN 1562-725X (Print)