The clinical efficiency of thrombolytic therapy in patients with lower-extremity acute deep venous thrombosis
Keywords:lower-extremity acute deep venous thrombosis, thrombolytic therapy, catheter-directed thrombolysis, low molecular weight heparin, unfractionated heparin
AbstractExamination and treatment of 138 patients with thrombosis in system of inferior vena cava were performed. Thrombolytic therapy (TLT) as the base method of treatment has been used in 52 (37.7%) patients. Catheter-directed thrombolysis has been realized in 20 (14.5%) patients and systemic thrombolytic therapy has been prescribed in 32 (23.2%) patients. Anticoagulant therapy (ACT) was the basic treatment in 86 (62.3%) patients. TLT results have significantly exceeded the ACP results in the distant period. So, clinical symptoms of post-thrombophlebitis disease (PTD) with severe chronic venous insufficiency (CVI) in the distant period have been observed in only 3 (6.4%) patients who were treated with thrombolytic therapy. At the same time, severe forms of PTD have been noted in 16 (24.6%) patients who were treated with ACT.
Венозний тромбоемболізм. Діагностика, лікування, профілактика / О. С. Ніконенко, В. В. Бойко, О. М. Скупий та ін. // Міждисциплінарні клінічні рекомендації. – Київ. – 2011. – 63 с.
Прасол В. А. Катетер-управляемый тромболизис и хирургические методы в лечении острого илиофеморального флеботромбоза/ В. А. Прасол // Международный медицинский журнал. – 2011. – №2(66). – С.35-39
Хронічні захворювання вен нижніх кінцівок і таза: діагностика, терапія, лікарсько-трудова експертиза, профілактика ускладнень / О. Ю. Усенко, П. І. Нікульніков, Л. М. Чернуха та ін. // Клініко-практичні рекомендації. – Київ. – 2014. – 120 с.
Allaert F. A. Meta-analysis of the impact of the principal venoactive drugs agents on malleolar venous edema / F. A. Allaert // Int. Angiol.– 2012.– Vol. 31 (4).– P. 310–315.
Catheter-based treatment of ilio-femoral deep vein thrombosis-An update on current evidence / J Fahrni, R. P. Engelberger, N. Kucher et al. / Vasa.– 2013. – Vol. 42. – P. 161-167.
Catheter-directed thrombolysis and stenting in the treatment of iliac vein com-pression syndrome with acute iliofemoral deep vein thrombosis: Outcome and follow-up. / G. H. Xue, X. Z. Huang, M. Ye, et al. Ann Vasc Surg. – 2014. – Vol. 28. – P. 957–963.
Catheter-directed thrombolysis of proximal lower extremity deep vein throm-bosis: A prospective trial with venographic and clinical follow-up. / H. Man-ninen, A. Juutilainen, E. Kaukanen, S. Lehto // Eur J Radiol. – 2012. – Vol. 81. – P. 1197–1202.
Cohen J. M. Pharmacologic and compression therapies for postthrombotic syndrome: a systematic review of randomized controlled trials / J. M. Cohen, E. A. Akl, S. R. Kahn // Chest. – 2012. – Vol. 141 (2). – P. 308–320.
Comerota A. J. Thrombolysis for deep venous thrombosis / A. J. Comerota // Journal of vascular surgery. – 2012. – Vol. 55 (2). – Р 607–611.
Epidemiology of chronic venous disorders in geographically diverse popula-tions: results from Vein Consult Program / E. Rabe, J. J. Guex, A. Puskas et al. // Int. Angiol. – 2012. – Vol. 31 (2). – P. 105–115.
Hull R. D. / Long-term low-molecular-weight heparin and the post-thrombotic syndrome: A systematic review. / R. D. Hull, J. Liang, G. Townshend. // Am J. Med. – 2011. – Vol. 124. – P. 756–765.
Therapy of catheter-directed thrombolysis for inferior vena cava thrombosis after filter implantation. / F. Lei, X. Li, A. Qian et al. // Zhonghua Yi Xue Za Zhi. – 2014. – Vol. 94. – P. 197–200.
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