The clinical efficiency of thrombolytic therapy in patients with lower-extremity acute deep venous thrombosis

D. V. Okley


Examination and treatment of 138 patients with thrombosis in system of inferior vena cava were performed. Thrombolytic therapy (TLT) as the base method of treatment has been used in 52 (37.7%) patients. Catheter-directed thrombolysis has been realized in 20 (14.5%) patients and systemic thrombolytic therapy has been prescribed in 32 (23.2%) patients. Anticoagulant therapy (ACT) was the basic treatment in 86 (62.3%) patients. TLT results have significantly exceeded the ACP results in the distant period. So, clinical symptoms of post-thrombophlebitis disease (PTD) with severe chronic venous insufficiency (CVI) in the distant period have been observed in only 3 (6.4%) patients who were treated with thrombolytic therapy. At the same time, severe forms of PTD have been noted in 16 (24.6%) patients who were treated with ACT.


lower-extremity acute deep venous thrombosis; thrombolytic therapy; catheter-directed thrombolysis; low molecular weight heparin; unfractionated heparin


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