Peculiarities of circadian dynamics of the antioxidant system and lipid peroxidation in rats

Authors

  • K. O. Kalko National University of Pharmacy, Ukraine
  • S. M. Drogovoz National University of Pharmacy, Ukraine
  • A. Yu. Pozdniakova National University of Pharmacy, Ukraine
  • N. V. Zacharko Rivne State Base Medical College, Ukraine

DOI:

https://doi.org/10.24959/cphj.15.1359

Keywords:

circadian rhythm, antioxidant system, female rats, male rats

Abstract

The activity of the liver as the central metabolic laboratory of an organism has a clear circadian rhythm due to the dependence of the daily flow of metabolic processes in the body. An important linking element of the cellular metabolism of circadian rhythms is the body’s antioxidant system (AOS) activity and lipid peroxidation (LPO). As a result of this research the circadian dependence of the LPO-AOS activity has been determined, however, not all of the components of the AOP system “work” equivalently during the day. According to the key components of the AOP activity the maximal “sustainability” of AOS is observed in the morning and the minimal – in the evening and at night. No significant sex differences between female-rats and male-rats have been found.

Author Biographies

K. O. Kalko, National University of Pharmacy

аспірант кафедри фармакології НФаУ

S. M. Drogovoz, National University of Pharmacy

професор кафедри фармакології

A. Yu. Pozdniakova, National University of Pharmacy

доцент кафедри фармакології

N. V. Zacharko, Rivne State Base Medical College

викладач фармацевтичних дисциплін, методист

References

Біохімія: підручник / за загальною редакцією проф. А. Л. Загайко, проф. К.В. Александрової. – Х.:Вид-во «Форт», 2014 – 728 с.

Бышевский А. Ш. Суточный ритм активности лимитирующих ферментов пентозофосфатного пути в печени крыс / А. Ш. Бышевский, Н. В. Колесник // Вопросы медицинской химии. – 1978.− Вып. 3. – С. 338-341.

Доклінічні дослідження лікарських засобів: Методичні рекомендації / За ред.: член-кор. АМН України О. В. Стефанова. – К.: Авіценна, 2001. – 528 с.

Камышников, В. С. Справочник по клинико-биохимической лабораторной диагностике: в 2т./ В. С. Камышников.− Мн.: Беларусь, 2000. – Т.1. – 495 с.

Реброва, О. Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA – 3-е изд. / О.Ю. Реброва. – М. :Ме¬диаСфера, 2006. – 312 с.

Парахонский А.П. Ритмическая природа иммунного ответа / А.П. Парахонский // Успехи современного естествознания. − №12. – 2006. – С. 68-69.

Семененко С. Б. Особливості структури хроноритмів екскреторної функції нирок за умов гіперфункції шишкоподібної залози / С. Б. Семененко // Буковинській медичний вісник. – Т. 18, № 2 (70). – 2014− С. 99-101.

Хронофармакология наглядно (Хронофармакология в таблицях и рисунках): Справочник – учебное пособие / С.М. Дроговоз [и др.]− Х.: Титул, 2014. − 128 с.

Circadian Orchestration of hepatic proteome / Akhilesh B. Reddy et al // Current Biology − №16. – 2006. − Р. 1107-1115.

Kalko K. O. Circadian rhythm of albumin and total protein contrnt in blood serum of intact rats and on the bacgraound of paracetamol hepatitis / K. O. Kalko, S. M. Drogovoz, A. Yu. Pozdniakova // Actual Questions of Development of New Drugs: Abstracts of International Scientific and Practical Conference of Young Scientists and Students (April 23-24, 2015). – Kh.: NUPh, 2015. – P. 317.

Shigenobu Shibata Neural regulation of the hepatic circadian rhytm / Shigenobu Shibata // The anatomical record. Part A – 2004. − Р. 901-909.

Tong X Circadian rhythms in liver physiology and liver diseases / X. Tong, L. Yin // Compr Physiol. − №3. – 2013. − Р. 917-940.

Rutter J. Metabolism and the control of circadian rhythms / J. Ratter et al // Annu. Rev. Biochem. – Vol.71. – 2002. – P. 307-331.

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Published

2015-12-01

Issue

Vol. 19 No. 4 (2015)

Section

Pre-clinical studies of new drugs

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