The study of the safety profile of “Altsinara” drug under the conditions of acute toxicity modeling

Authors

  • A. Tattis National University of Pharmacy, Ukraine
  • I. A. Zupanets National University of Pharmacy, Ukraine
  • I. A. Otrishko National University of Pharmacy, Ukraine
  • I. F. Grintsov National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/cphj.15.1350

Keywords:

drug, “Altsinara”, toxicological profile, acute toxicity

Abstract

The results of preclinical safety study of the drug "Altsinara", tablets for oral use produced by the private joint stock company SPC "Borschagovsky CPP". During the acute toxicity studies it has been defined that the single intragastric administration once it doesn’t have toxic effects on the general condition and behavior of animals, do not cause their death, as well as visible changes in the internal organs. The absence of lethality when administered "Altsinara" suggests that the LD50 for this drug exceeds the maximum dose that was used in the experiment, so in case of intragastric LD50 of "Altsinara" is more than 5000 mg/kg on the amount of active ingredients. This LD50 value can be referred to the drug "Altsinara" studied at the route of administration on the standard classification of K. K Sidorov to the V class of toxicity as a practically non-toxic substances. Thus, the results of the study indicate that "Altsinara" is the drug nearly safety for humans, almost have no toxic effects on the body after a single administration.

Author Biography

A. Tattis, National University of Pharmacy

 

 

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Published

2015-09-10

Issue

Vol. 19 No. 3 (2015)

Section

Pre-clinical studies of new drugs

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