Analysis of consumption of macrolides in Ukraine


  • N. O. Matyashova National University of Pharmacy, Ukraine
  • L. V. Iakovlieva National University of Pharmacy, Ukraine



antimicrobials, pharmacoeconomic analysis, pharmacoepidemiology, macrolides, bacterial infections


The structure of the pharmaceutical market of antibiotics of the macrolide group in Ukraine has been analysed. The analysis has been conducted on the basis of the outpatient consumption of drugs within 4 years in Ukraine using the ATC/DDD methodology, which is of particular interest to the society in terms of health, social and economic consequences of the irrational use and allows performing a long-term research at different levels of drug consumption. In the course of our study, the indicator DDDs/1000 inhabitants/day, which gives an idea of the proportion of people receiving a certain type of treatment, has been calculated. The analysis has revealed that azithromycin is the most consumed drug for the whole of study. At the end of the study period in 2013 the indicators of consumption increased by 27% compared to 2010. The second place in terms of consumption in DDDs/1000 inhabitants /day is occupied by medicines based on clarithromycin. Medicines on the basis of erythromycin were used in slightly different dynamics: consumption decreased with time, and by 2013 it led to decrease by 20% compared to 2010. The same tendency is observed when consuming spiramycin and midecamycin. These medicines are natural macrolide antibiotics. There is a positive tendency in consumption of macrolides: increase in the total volume of consumption by 30% in 2013 compared to 2010. This tendency is observed in other countries as well.


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