The experience of intestinal microflora restoration in patient with acute and chronic myeloid leukemia

L. M. Nemyrovska, A. P. Rybalska


The absence of disorders of the intestinal microecology enables to reduce the risk of infectious complications by preventing the translocation of opportunistic pathogenic bacteria in the biotopes of the upper respiratory tract and allows to conduct the courses of anticancer therapy in patients with leukemia of the myeloid origin. The aim of our research was to restore the microecology of the intestine in patients with acute (AML) and chronic (CML) myeloid leukemia. As result of monitoring of the intestinal microecology in 85.7% of patients with AML and in 70.4% with CML anaerobes of Bifidobacterium genus have not been found; bacteria of Lactobacillus genus have been isolated from the intestine of 57.1% of patients with CML and 71.4% with AML (in one third of the patients its quantity was lower than the physiological norm (103-107 CFU/g). After the course of probiotic therapy bifidobacteria were isolated from the biotope of all patients, lactobacteria – from the intestine of all CML patients and 83.3% of the patients with AML, in the second group the bacterial titres increased (from 103-108 CFU/g tо 106-109 CFU/g). At first E. coli were isolated in low titres (101-103 CFU/g), and after termination – within the physiological norm (106-108 CFU/g). When conducting probiotic therapy the titres of opportunistic pathogenic bacteria did not increase or decreased by 10 times. Probiotic therapy allows to restore the normal microecology of the intestine, improve the physiological state and timely conduct the courses of polychemotherapy in AML and CML patients.


AML and CML patients; opportunistic pathogenic bacteria; probiotic therapy; microecology of the intestine


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Abbreviated key title: Clin. pharm.

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