The experience of intestinal microflora restoration in patient with acute and chronic myeloid leukemia
DOI:
https://doi.org/10.24959/cphj.14.1329Keywords:
AML and CML patients, opportunistic pathogenic bacteria, probiotic therapy, microecology of the intestineAbstract
The absence of disorders of the intestinal microecology enables to reduce the risk of infectious complications by preventing the translocation of opportunistic pathogenic bacteria in the biotopes of the upper respiratory tract and allows to conduct the courses of anticancer therapy in patients with leukemia of the myeloid origin. The aim of our research was to restore the microecology of the intestine in patients with acute (AML) and chronic (CML) myeloid leukemia. As result of monitoring of the intestinal microecology in 85.7% of patients with AML and in 70.4% with CML anaerobes of Bifidobacterium genus have not been found; bacteria of Lactobacillus genus have been isolated from the intestine of 57.1% of patients with CML and 71.4% with AML (in one third of the patients its quantity was lower than the physiological norm (103-107 CFU/g). After the course of probiotic therapy bifidobacteria were isolated from the biotope of all patients, lactobacteria – from the intestine of all CML patients and 83.3% of the patients with AML, in the second group the bacterial titres increased (from 103-108 CFU/g tо 106-109 CFU/g). At first E. coli were isolated in low titres (101-103 CFU/g), and after termination – within the physiological norm (106-108 CFU/g). When conducting probiotic therapy the titres of opportunistic pathogenic bacteria did not increase or decreased by 10 times. Probiotic therapy allows to restore the normal microecology of the intestine, improve the physiological state and timely conduct the courses of polychemotherapy in AML and CML patients.
References
Бактериологическое исследование кала на дисбактериоз: Метод. рекоменд. – 1998. – 12 с.
Бондаренко В.М., Рябиченко Е.В. // Журн. микробиол., эпидемиол. и иммунобиол. – 2010. – №1. – С. 92-100.
Габриэлян Н.И., Горская Е.М., Спирина Т.С., Преображенская Т.Б. // Журн. микробиол., эпидемиол. и иммунобиол. – 2007. – №4. – С. 50-53.
Зорина В.В., Николаева Т.Н., Шаповалова О.В. // Журн. микробиол., эпидемиол. и иммунобиол. – 2006. – №6. – С. 40-44.
Катаева Л.В., Степанова К.Б., Степанова Т.Ф. и др. // Журн. микробиол., эпидемиол. и иммунобиол. – 2010. – №1. – С. 76-80.
Клясова Г.А., Сперанская Л.Л., Миронова А.В. и др. // Гематол. и трансфузиол. – 2007. – Т. 52, №1. – С. 11-18.
Макушенко А.С. // Лабораторная диагностика. – 2002. – №3. – С. 43-45.
Определитель бактерий Берджи / Под ред. Дж.Хоулта. – М.: Мир, 1997. – 800 с.
Рибальська А.П., Немировська Л.М., Скачкова Н.К. та ін. // Укр. журн. гематол. та трансфузіол. – 2003. – №3. – С. 28-32.
Савицкая И.С., Бондаренко В.М. // Журн. микробиол., эпидемиол. и иммунобиол. – 2008. – №3. – С. 53-58.
Третяк Н.М., Рибальська А.П., Басова О.В. та ін. // Укр. журн. гематол. та трансфузіол. – 2009. – №4. – С. 39-43.
Янковский Д.С. Микробная экология человека: современные возможности ее поддержания и восстановления. – К.: Эксперт ЛТД, 2005. – 361 с.
Downloads
Published
Issue
Section
License
Copyright (c) 2014 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
