The antibacterial activity of lipophiliccomplexes from bedstraws against microorganisms of enterobacteriaceae family

Authors

  • O. V. Goryacha National University of Pharmacy, Ukraine
  • N. V. Kashpur SI «Institute of microbiology and immunology n.I.I.Mechnikov NAMS», Ukraine
  • T. V. Ilyina National University of Pharmacy, Ukraine
  • A. M. Kovalyova National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/cphj.14.1320

Keywords:

bedstraws, lipophilic complexes, antibacterial activity, method of serial dilutions

Abstract

A high level of antibiotic resistance of representatives of Escherichia, Proteus, Klebsiella, Shigella and Salmonella genus makes urgent and prospective the search of new substances that are active in relation to these microorganisms. For the first time the antibacterial activity of lipophilic complexes of biologically active substances (BAS) from bedstraw species of the Ukrainian flora in relation to 11 test strains of Enterobacteriaceae family has been found. The lipophilic complex of Galium cruciata herb (Cruciata laevipez) revealed the highest activity against the test cultures. Microorganisms of Escherichia, Klebsiella and Salmonella genus were highly sensitive (MIC was 31.25 μg/ml; MBC was 62.5 μg/ml), test strains of Proteus and Shigella showed a moderate sensitivity to this lipophilic complex (MIC – 125 μg/ml; MBC – 250 μg/ml). All the test strains revealed a low sensitivity to the lipophilic complexes of BAS from Galium verum and Galium salicifolium herbs. The range of microorganisms sensitivity can be an indirect argument for systematic transfer of cruciform bedstraw to Cruciata genus under the name of Cruciata laevipez. 

References

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Published

2014-12-01

Issue

Vol. 18 No. 4 (2014)

Section

Pre-clinical studies of new drugs

License

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