Methodology of creating rectal drugs for the treatment of prostate diseases
DOI:
https://doi.org/10.24959/cphj.14.1311Keywords:
suppositories, methodology, research algorithm, technologyAbstract
The methodology of creating the suppositories for the treatment of prostate diseases has been grounded. Benign prostatic hyperplasia (BPH) and chronic prostatitis are among the most common urologic diseases in men. In recent years, at the pharmaceutical market a lot of drugs – prostate protectors of both domestic and foreign production have appeared; among them the prominent place is occupied by α-adrenoblockers, and phytotherapeutic drugs. One way to solve the problem of effective treatment of prostate diseases is the use of suppositories, which have a number of significant advantages over other dosage forms. At present there are no medicines with α-adrenoblockers and herbal compositions with plant extracts in the form of suppositories at the pharmaceutical market. To provide the efficacy and safety of suppositories all pharmaceutical factors affecting the drug quality should be theoretically and experimentally grounded. They are the nature and amount of the base, physical and chemical properties of active substances and excipients (solubility, dispersion degree, trace element composition), structural and mechanical properties and equipment. To ensure the therapeutic efficacy of the drug the biopharmaceutical research on the release of active substances from different suppository bases is important, as well as the comparison of active substances accumulation in the blood and prostate after oral and rectal administration. Thus, using the general methodological approach to pharmaceutical development the authors have grounded the methodology and made the plan of experimental studies on creation of rectal suppositories based on synthetic and natural substances for the treatment of prostate diseases, which in the future may be the drugs of choice at the domestic pharmaceutical market.
References
Компендиум 2013 – лекарственные препараты / Под ред. В.Н.Коваленко – К.: МОРИОН, 2013. – 2360 с.
Мирошников В.М. Лекарственные растения и препараты растительного происхождения в урологии: Учебное пособие. – М.: МЕДпресс-информ, 2005. – 240 с.
Простатит / Под ред. П.А.Щеплева. – М.: МЕДпресс-информ, 2007. – 224 с.
Рациональная фармакотерапия в урологии: Руководство для практикующих врачей / Под ред. Н.А.Лопаткина. – М.: Литтера, 2006. – 824 с.
Тиктинский О.Л., Калинина С.Н., Михайличенко В.В. Андрология. – М.: ООО «Медицинское информационное агентство», 2010. – 576 с.
Ваrry S.J., Coffey D.S., Walsh P.C. // J. Urol. – 2004. – Vol. 132. – P. 474-479.
Bergman J., Zeitlin S.I. // Expert. Rev. Neurother. – 2007. – Vol. 7, №3. – P. 301-307.
Brede C.M., Shoskes D.A. // Nat. Rev. Urol. – 2011. – Vol. 8 (4). – P. 207-212.
Wagenlehner F.M., Weidner W., Naber K.G. // Expert. Opin. Pharmacother. – 2007. – Vol. 11, №8. – P. 1667-1674.
Weidner W., Rusz A., Pilatz A. et al. // J. Urol. – 2011. – Vol. 17 (3). – P. 192-196.
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