DOI: https://doi.org/10.24959/cphj.14.1296

Research of the hepatoprotective activity of sweet woodruff dry extract

N. S. Iurchenko, T. V. Ilyina, A. M. Kovalyova, A. O. Klymenko, V. M. Ivanochko

Abstract


Sweet woodruff (Asperula odorata L.) of Rubiaceae Juss. family is not officinal plant, which is used in folk medicine as a sedative, diuretic and choleretic agent. The hepatoprotective activity of a dry extract of sweet woodruff herb has been determined experimentally on the model of the acute toxic liver damage in rats. It has been found that the extract of sweet woodruff in the dose of 25 mg/kg reduces the intensity of lipid peroxidation, normalizes biochemical indicators of the animal blood and the liver homogenate to the level of intact animals, decreases toxic effects of tetrachlormethane. Moreover, the activity of ALT and AST in the blood serum decreases by 2.2 and 2.1 times, respectively; the cholinesterase activity increases by 13%, the level of TBA-reagents in the blood serum and the liver tissue decreases by 1.3 and 1.6 times, respectively, compared to the control group of animals. To confirm the results of the research the study of the histological structure of the liver of the experimental animals has been carried out. While studying the histology of the liver in treated animals the degenerative changes and the phenomenon of structural degradation and signs of severe hemodynamic disorders have not been detected. By its hepatoprotective action the sweet woodruff extract is practically not inferior to the reference drug Silibor.


Keywords


sweet woodruff; hepatoprotective activity; dry extract

Full Text:

PDF

References


Доклінічні дослідження лікарських засобів: Метод. рекоменд. / Під ред. О.В.Стефанова. – К.: Авіценна, 2001. – 528 с.

Коробейникова Е.Н. // Лаб. дело. – 1989. – №7. – С. 8-10.

Лабораторные методы исследования в клинике / Под ред. В.В.Меньшикова. – М.: Медицина, 1987. – C. 189-190.

Лікарські рослини: Енциклопед. довідник / Відп. ред. А.М.Гродзінський. – К.: Голов. ред. УРЕ, 1990. – 544 с.

Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ / Под ред. Р.У.Хабриева. – М.: Медицина, 2005. – 832 с.

Юрченко Н.С., Ільїна Т.В., Ковальова А.М. // Укр. біофармац. журн. – 2012. – №5-6 (22-23). – С. 104-107.

Юрченко Н.С., Ільїна Т.В., Ковальова А.М. // Укр. мед. альманах. Матер. Всеукр. наук.-практ. конф. зa міжнар. участю «Актуальні питання експериментальної, клінічної медицини та фармації» (25-26 жовтня 2012 р.). – 2012. – Т. 15, №5 (додаток). – С. 292-294.

Ramachandran R., Kakar S. // J. Clin. Pathol. – 2009. – Vol. 62. – P. 481-492.

Yurchenko N.S., Il’ina T.V., Kovaleva A.M. // Chemistry of Natural Compounds. – 2013. – Vol. 49, №2. – P. 401-402. [Russian original №2. March-April, 2013, pp. 337-338].


GOST Style Citations






Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Abbreviated key title: Clin. pharm.

ISSN 2518-1572 (Online), ISSN 1562-725X (Print)