The study of toxicological properties of “metroxal” cream

L. M. Maloshtan, V. Ye. Yurchenko, N. P. Polovko, I. O. Tymoshyna

Abstract


The presence of Demodex folliculorum mites exacerbates the number of dermatological conditions, such as rosacea and perioral dermatitis, and complicates their treatment. Development and introduction of medicines with the complex action in practical medicine exhibiting anti-parasitic properties against Demodex folliculorum and possessing the antibacterial, anti-inflammatory, capillary-restorative, anti-edemic, antioxidant and anti-allergic effect are of great current interest. One of the stages of introduction of new medicines is to study toxicity, which allows to assess their safety. Acute toxicity, the skin-irritant effect of the cream containing metronidazole, salicylic acid, troxerutin and essential oil of lemon balm, as well as its anti-alterative activity have been experimentally investigated on the model of non-allergic contact subchronic dermatitis caused by turpentine. The results obtained show no toxicity and skin-irritant effect of the cream with a single topical application to rats in the doses of 500 and 15000 mg/kg; it allows to refer it to Class VI of practically non-toxic substances (LD > 15000 mg/kg) in accordance with the generally accepted classification of K.K.Sidorov. As a result of the study of the anti-alternative activity on the model of non-allergic contact subchronic dermatitis caused by turpentine it has been found that the cream under research reveals the anti-inflammatory action.


Keywords


dermatological diseases; toxicological research; creams

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References


Глянц С. Медико-биологическая статистика / Пер. с англ. – М.: Практика, 1998. – 459 с.

Доклінічні дослідження лікарських засобів: Метод. рекоменд. / Под ред. О.В. Стефанова. – К.: Авіценна, 2001. – 528 с.

Иванов Ю.И., Погорелюк Р.Н. Статистическая обработка результатов медико-биологических исследований на микрокалькуляторах по программам. – М.: Медицина, 1990. – 224 с.

Коган Б.Г., Степаненко В.І. // Укр. журн. дерматол., венерол., косметол. – 2006. – №1. – С. 14-28.

Коган Б.Г., Горголь В.Т., Степаненко В.І. та ін. // Укр. журн. дерматол., венерол., косметол. – 2002. – №4. – С. 50-54.

Компендиум 2008 – Лекарственные препараты: Справ. / Под ред. В.Н.Коваленко, А.П.Викторова. – К.: Морион, 2008. – 2120 с.

Лапач С.М., Чубенко А.В., Бабіч П.М. Статистичні методи в медико-біологічних дослідженнях із застосуванням Exсel. – К.: Моріон, 2001. – 408 с.

Рябченко И.Н. // Укр. журн. дерматол., венерол., косметол. – 2007. – №3. – С. 93-95.

Dahl M.V., Jarratt M., Kaplan D. // J. Am. Acad. Dermatol. – 2001. – Vol. 45. – P. 723-730.

Desch C.E., Nutting W.B. // Acarol. – 2007. – Vol. 19, №3. – Р. 422-462.

Nultinff W.B., Geer A.C. // Br. J. Dermatol. – 2006. – Vol. 9, №4. – P. 34-38.


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DOI: https://doi.org/10.24959/cphj.14.1264

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Abbreviated key title: Klìn. farm.

ISSN 2518-1572 (Online), ISSN 1562-725X (Print)