The study of toxicological properties of “metroxal” cream

L. M. Maloshtan, V. Ye. Yurchenko, N. P. Polovko, I. O. Tymoshyna


The presence of Demodex folliculorum mites exacerbates the number of dermatological conditions, such as rosacea and perioral dermatitis, and complicates their treatment. Development and introduction of medicines with the complex action in practical medicine exhibiting anti-parasitic properties against Demodex folliculorum and possessing the antibacterial, anti-inflammatory, capillary-restorative, anti-edemic, antioxidant and anti-allergic effect are of great current interest. One of the stages of introduction of new medicines is to study toxicity, which allows to assess their safety. Acute toxicity, the skin-irritant effect of the cream containing metronidazole, salicylic acid, troxerutin and essential oil of lemon balm, as well as its anti-alterative activity have been experimentally investigated on the model of non-allergic contact subchronic dermatitis caused by turpentine. The results obtained show no toxicity and skin-irritant effect of the cream with a single topical application to rats in the doses of 500 and 15000 mg/kg; it allows to refer it to Class VI of practically non-toxic substances (LD > 15000 mg/kg) in accordance with the generally accepted classification of K.K.Sidorov. As a result of the study of the anti-alternative activity on the model of non-allergic contact subchronic dermatitis caused by turpentine it has been found that the cream under research reveals the anti-inflammatory action.


dermatological diseases; toxicological research; creams

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