Ways of medicinal prevention and treatment of doxorubicin-induced cardiomyopathy in oncological patients





doxorubicin-induced cardiomyopathy, chemotherapy, malignant neoplasms, myocardial dysfunction and heart failure, drug side effects


The high incidence of malignant tumors is currently supported by the general ageing of the world population and unfavorable environmental factors. In 2018, 18.1 million new cases of cancer and 9.6 million deaths from them were registered in the world. At the same time, a significant increase in the life expectancy of these patients after the treatment noted over the past 20 years highlights the problem of side effects of the anticancer therapy. One of the most serious side effects is the development of doxorubicin-induced cardiomyopathy (DRIC). In all three distinct clinical forms (acute, early and late) DRIC can develop in 58 % of patients after using anticancer treatment regimens with the inclusion of doxorubicin. The review provides a detailed analysis of medicinal treatment regimens and preparations (ACE inhibitors, beta-blockers, statins, etc.) currently used, and evaluates their effectiveness and expected results. Currently, several therapeutic strategies have been proposed for the prevention and treatment of DRIC, each of them has certain positive results. At the same time, some therapeutic methods used in the clinic have some disadvantages.

Conclusions. The limitations of the results of DRIC prevention achieved by the existing therapeutic regimens, as well as the possibilities for their prediction, have been stated. The need for further research to improve the effectiveness of medicinal prevention and treatment of DRIC is emphasized.

Author Biographies

V.A. Moroz, National University of Pharmacy of the Ministry of Health of Ukraine

Doctor of Medicine (Dr. habil.), professor of the Clinical Pharmacology and Clinical Pharmacy Department

R.A. Al-Hadrawi, Al Hakeem Hospital

oncologist, Master of Medicine, Department of Oncology

O.O. Andrieieva, National University of Pharmacy of the Ministry of Health of Ukraine

Candidate of Pharmacy (Ph.D.), associate professor of the Department of Clinical Pharmacology and Clinical Pharmacy

Yu.V. Timchenko, National University of Pharmacy of the Ministry of Health of Ukraine

Candidate of Medicine (Ph.D.), teaching assistant of the Department of Clinical Pharmacology and Clinical Pharmacy

A.M. Semenov, National University of Pharmacy of the Ministry of Health of Ukraine

Candidate of Medicine (Ph.D.), associate professor of the Department of Clinical Pharmacology and Clinical Pharmacy


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Clinical Pharmacology and Pharmacotherapy