Conservative therapy of chronic heart failure: glyflosins destroy the worldview




cardiac insufficiency, gliflozins, dapagliflozin, cardioprotective mechanism, new indication for administration


Medications representing a new class of drugs – inhibitors of sodium-glucose transport protein type 2 (SGLT2 inhibitors, gliflozins) have appeared in the clinical practice relatively recently. Now they are a new hope for the treatment of chronic heart failure (HF) in patients with/without type 2 diabetes mellitus (DM2). The article briefly discusses the main mechanisms of action of gliflozins, which allowed their active use in clinical practice, in particular, the ability of gliflosins to affect the size and the functional activity of epicardial adipose tissue, as well as the state of the sympathetic nervous system, thereby preventing the development of HF. The main results of the large-scale randomized clinical trials, such as CANVAS, CREDENCE, EMPA, EMPAREG OUTCOME, DECLARE-TIMI 58 are presented. They analyze the effects of canagliflozin, empagliflozin, dapagliflozin on various cardiovascular outcomes: cardiovascular death, myocardial infarction, nonfatal stroke, HF, frequency of hospitalizations caused by HF. Modern concepts of the probable mechanisms of the cardioprotective action of gliflozins are given. The results of meta-analyses revealing the possibility of including gliflozins in the treatment of HF, DM2, as well as those who studied the cardiovascular safety of this drugs have been analyzed. The results of a recently published international trial DAPAHF studied the cardioprotective properties of dapagliflozin in HF, have been considered. The unique pleotropic cardiovascular properties of SGLT2 inhibitors (dapagliflozin) and their ability to prevent the progression of HF and reduce cardiovascular mortality allow us to hope that these drugs have a specific cardioprotective activity with respect to the treatment of HF with the reduced and preserved ejection fraction. Glyflosins, particularly dapagliflozine, are believed to be the fifth class of drugs recommended for the treatment of CH withthe reduced left volume ejection fraction, regardless of the presence or absence of DM2.

Conclusions. It is expected that the results of the new studies will demonstrate the additional advantages of SGLT2 inhibitors in patients with and without cardiovascular diseases, CH with and without of DM2 and will help to better understand the mechanisms of their action, change approaches to the treatment of many patients.

Author Biographies

I. G. Kravchenko, Government Institution “National Institute of Therapy named after L. T. Malaya of NAMS of Ukraine”

Candidate of Medicine (Ph.D.), senior researcher of the Department of Clinical Pharmacology and Pharmacogenetics of Noncommunicable Diseases

Yu. S. Rudyk, Government Institution “National Institute of Therapy named after L. T. Malaya of NAMS of Ukraine”

Doctor of Medicine (Dr.habil.), head of the Department of Clinical Pharmacology and Pharmacogenetics of Noncommunicable Diseases

O. O. Medentseva, Government Institution “National Institute of Therapy named after L. T. Malaya of NAMS of Ukraine”

Candidate of Medicine (Ph.D.), researcher of the Department of Clinical Pharmacology and Pharmacogenetics of Noncommunicable Diseases

M. E. Chernenok, Taras Shevchenko National University Chernihiv College

Candidate of Medicine (Ph.D.), associate professor of the Department of Biological Foundations of Physical Education, Health and Sports


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Clinical Pharmacology and Pharmacotherapy