Carboxytherapy as an innovative method in cosmetology

A. V. Kononenko, S. M. Drogovoz, N. V. Grishchenko, L. B. Ivantsyk, N. Ya. Asadullaeva, A. L. Stroblya

Abstract


Carboxytherapy is a new method of anti-aging treatments for the skin, which has clinically confirmed its efficacy and safety, and has good prospects of application in cosmetology. However, there is no systematization of the information about the mechanisms of action that can substantiate its use in cosmetics and pharmacy. Therefore, the aim of this review is to study the mechanisms of action of local effects of CO2 in cosmetology. In cosmetology the effect of carboxytherapy is provided by multifactorial mechanisms of reflex hemosensor (the impact on chemoreceptors), mechanical reflex (Zecharia zone-Ged, baroreceptors), biochemical (the change in the CO2 concentration in the blood), which create the conditions for the system of self-regulation and support in the skin. It is due to the polyvalent mechanism of action the CO2 therapy pharmacodynamics in cosmetology includes a variety of local and resorptive effects on the skin: increased vasodilation, oxygenation, neovasculization of the blood- and lymph flow; restoration of elasticity and the skin turgor; smoothing of photo-aging signs (the anti-aging effect); lifting and smoothing of wrinkles; relief of stress and skin fatigue; the qualitative improvement of the skin texture; lighting and colour alignment; reduction of swelling and pastosity; strengthening the skin around the eyes; the immunity restoration and removal of the skin inflammation (acne, rosacea); the antibacterial effect (elimination of bacteria that cause acne scars); stimulation of angiogenesis and inhibition of melanogenesis; reduction in the local adipose tissue (lipolysis); eliminatation of toxins; intensification of the sweat and sebaceous glands function. Carboxytherapy helps when the signs of the skin aging (wrinkles and double chin) appear, contributes to the figure correction (cellulitis), eliminates many cosmetic defects (stretch marks, dark circles), and promotes to the skin restoration after aggressive methods of rejuvenation and rehabilitation after burns.


Keywords


carboxytherapy; carbon dioxide; collagen; neovasculization; regeneration

References


Андріюк Л.В., Зав’ялова О.Р., Мацко Н.В. Застосування вуглекислого газу в медичній реабілітації: Метод. рекоменд. – Л., 2014. – 206 с.

Дроговоз С.М., Штрыголь С.Ю., Зупанец М.В. и др. // Клінічна фармація. – 2016. – Т. 20, №1. – С. 12-17.

Дроговоз С.М., Штрыголь С.Ю., Зупанец М.В. и др. // Медична та клінічна хімія. – 2016. – Т. 18, №1. – С. 112-116.

Зеленкова Г. // Дерматол. для практики. – 2014. – T. 8, №2. – C. 72-74.

Румянцева Е., Блидар С. // Инъекционные методы в косметологии. – 2010. – №1. – С. 46-52.

Amuso D. // Aesthetics. – 2014. – Vol. 1, №12. – P. 46-47.

Bayat M., Fridoni M., Nejati H. et al. // J. of Lasers in Medical Sciences. – 2015. – Vol. 30, №3. – P. 1124-1137.

Brandi C., D’Aniello C., Grimaldi L. et al. // Aesthetic Plastic Surgery. – 2004. – Vol. 28. – P. 222-225.

Brandi C., Grimaldi L., Nisi G. et al. // In Vivo. – 2010. – Vol. 24, №2. – P. 223-226.

Brandi C., D’Aniello C., Grimaldi L. et al. // Aesthetic Plastic Surgery. – 2001. – Vol. 25, №3. – P. 170-174.

Brockow T., Hausne T., Dillner A., Reasch K.L. // BMC Complementary and Alternative Medicine. – 2000. – Vol. 6, №5. – P. 391-403.

Campana M., Vaccaro M., Perello R. et al. // Rivista Italiana di Chirurgia Plastica – Clinical and Experimental Plastic Surgery. – 2009. – Vol. 41. – P. 165-170.

Campos V., Bloch L., Cordeiro T. // J. of the American Academy of Dermatol. – 2007. – Vol. 56, №2, Suppl.2. – P. AB196.

Corassa J.M., Pereira F.L.C., Penha M.R., Corassa M.P. // Revista de Angiol. e Cirurgia Vascular. – 2006. – Vol. 8. – P. 3-6.

Costa С.S., Otoch J.P., Seelaender M.C. et al. // The J. of the Brazilian College of Surgeons. – 2011. – Vol. 38, №1. – P. 015-022.

De Goursac C. // Le Journal de Medicine Esthétique et Chirurgie Dermatologique. – 2010. – №145. – P. 11-19.

Duraes E.F., Duares L., Carneiro F.C. et al. // Acta Cirurgica Brasileira. – 2013. – Vol. 28, №8. – 589 с.

Ferreira J.C., Haddad A., Tavares S.A. // J. of Drugs in Dermatol. – 2008. – Vol. 7, №3. – P. 201-206.

Hall E.L., Driver I.D., Croal P.L. et al. // NeuroImage. – 2011. – Vol. 58, №4. – P. 1034-1043.

Irie H., Tatsumi T., Takamiya M. et al. // Circulation. – 2005. – Vol. 111, №12. – P. 1523-1529.

Jensen F.B. // Acta Physiol. Scandinavica. – 2004. – Vol. 182, №3. – P. 215-227.

Koutna N. // Časopis lékařů českých. – 2006. – №145. – P. 841-843.

Koutna N. Carboxytherapy in Aesthetic Medice. – Berlin: Springer-Verlag, 2011. – P. 547-576.

Lee C.M., Huxley R.R., Wildman R.P., Woodward M. // J. of Clinical Epidemiol. – 2008. – Vol. 61, №8. – P. 648-653.

Lee G.S.K. // Aesthetic Plastic Surgery. – 2010. – Vol. 34, №2. – P. 239-243.

Lee G.S.K. // J. of Cosmetic Dermatol. – 2016. – Vol. 1. – P. 1-9.

Lopez J.C. // Abstracts of 5th European Congress of Aesthetic Medicin, Paris, 25-26 April 2006. – Paris, 2006. – P. 42-45.

Maia-Figueirу T.L., Odashiro A.N., Menezes G.P. et al. // J. of Cosmetics, Dermatol. Sci. and Applications. – 2012. – Vol. 02, №03. – P. 164-173.

Moreton F.C., Dani K.A., Goutcher C. et al. // NeuroImage: Clinical. – 2016. – Vol. 11. – P. 667-677.

Muzi F., Delicato G., D’Andria D. et al. // J. of Pharmacy and Pharmacol. – 2015. – Vol. 3 – P. 405-410.

Nach R., Zandifar Н., Gupta R., Hamilton J. // Ear, Nose and Throat J. – 2010. – Vol. 89, №2. – Р. 64-66.

Paolo F., Nefer F., Paola P. et al. // J. of Cosmetic Dermatol. – 2012. – Vol. 11. – P. 223-228.

Pianez L.R., Custódio F.S., Guidi R.M. et al. // Clinical, Cosmetic and Investigational Dermatol. – 2016. –

Vol. 9. – P. 183-190.

Piazzolla L.P., Louzada L.L., Scoralick F.M. et al. // J. of the American Geriatrics Society. – 2012. – Vol. 60,

№2. – P. 378-379.

Ranucci M., Carboni G., Cotza M., de Somer F. // Perfusion. – 2016. – Vol. 31, №5. – P. 4.

Sinozic T., Kovacevic J. // Acta Medica Croatica. – 2013. – Vol. 67, Suppl 1. – P. 137-141.

Sönmez A., Yaman M., Yalçin O. et al. // An International J. of Surgical Reconstruction. – 2009. – Vol. 62,

№7. – P. 236-237.

Taylor C.T., Cummins E.P. // The J. of Physiol. – 2011. – Vol. 589, №4. – P. 797-803.

Valaro V., Bartoletti C.A. // La Medicina Estetica. – Roma, 2005. – Vol. 29, №3. – P. 417-438.

Vallee F., Vallet B., Mathe O. et al. // Intensive Care Medicine. – 2008. – Vol. 17. – P. 2218-2225.

Varlaro V., Manzo G., Mugnaini F. et al. // Acta Phlebol. – 2007. – Vol. 8, №2. – P. 79-91.

Zenker S. // Prime. – 2012. – Vol. 2, №1. – P. 42-50.


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DOI: https://doi.org/10.24959/cphj.16.1410

Abbreviated key title: Klìn. farm.

ISSN 2518-1572 (Online), ISSN 1562-725X (Print)