The effect of the compositioin containing the combination of doxycycline hydrochloride and glucosamine hydrochloride on the structural and metabolite indicators in rats with collagen-induced arthritis

Authors

  • I. A. Zupanets National University of Pharmacy, Ukraine
  • K. M. Tkachenko National University of Pharmacy, Ukraine
  • I. A. Otrishko National University of Pharmacy, Ukraine
  • S. K. Shebeko National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/cphj.16.1375

Keywords:

doxycycline hydrochloride, glucosamine hydrochloride, combination, diclofenac sodium, collagen-induced arthritis

Abstract

In the model of collagen-induced arthritis in rats studied anti-inflammatory properties of compositions based on a combination of doxycycline hydrochloride and glucosamine hydrochloride in comparative aspect with its active monokomponentamy - doxycycline, glucosamine hydrochloride. As a result of experimental studies demonstrated that a composition based on a combination of doxycycline hydrochloride and glucosamine hydrochloride, exhibits a pronounced beneficial effect on indicators of exchange cartilage and bone on the background of autoimmune arthritis and leads to inhibition of immunoinflammatory processes in the connective tissue of animals. The noted normalization of the functional state of the joints and clinical and biochemical parameters. The degree of pharmacological effect on most studied parameters combination (D+HA) exceeds a reference facility - the substance doxycycline hydrochloride and glucosamine. Composition (D+HA) is a promising proof-inflammatory and destructive joint disease with an autoimmune component and can be recommended for use in complex therapy of patients with inflammatory and immune-inflammatory-destructive diseases of the joints.

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Published

2016-03-11

Issue

Vol. 20 No. 1 (2016)

Section

Pre-clinical studies of new drugs

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