The microbiological analysis of the effectiveness of modern antiseptics and antimicrobial materials
DOI:
https://doi.org/10.24959/cphj.14.1324Keywords:
antiseptics, decasan®, miramistin, chlorhexidine, dressings, pyo-inflammatory processesAbstract
Effectiveness of antiseptics decasan®(DC), chlorhexidine digluconate (CH), miramistin (MR), antimicrobial composition of decamethoxin (AMC, patent N 74853, Ukraine), antimicrobial dressings against isolated strains of S. aureus (n 32), E. coli (n 25), P. aeruginosa (n 20), C. albicans (n 16) in patients with diabetes having pyo-inflammatory complications has been researched. The antimicrobial properties of antiseptics have been studied by means of the serial dilutions method. The antimicrobial activity of dressings (1.0x1.0 cm), such as medical cotton impregnated with AMC; antiseptic overlay with CH (AOCH); Traumastem Biodress Disinfect®(TBD); activtex CH®, activtex CHF®, against clinical isolates of microorganisms has been studied on solid media. The bactericidal action against S. aureus in the presence of AMC (1.4±0.2 mkg/ml), DC (1.73±0.2 mkg/ml); CH (12.8±2.1 mkg/ml); MR (8.3±0.9 mkg/ml) has been found. The bactericidal properties of DC and MR in relation to E. coli in their concentrations of 6.68±0.71 and 17.9±1.9 mkg/ml, respectively, have been determined. AMC (4.9±0.5 mkg/ml) was six times more active than CH (p<0.001). The antipseudomonal action of DC against P. aeruginosa was 1.5 times higher than CH. AMC had also 2.8 times higher activity (p<0.001). The bactericidal action of MR was registered in the presence of 72.9±2.2 mkg/ml. It has been found that C. albicans is sensitive to AMC (7.4±1.9 mkg/ml), DC (14.6±1.9 mkg/ml), MR (26.0±3.6 mkg/ml). CH has a low effectiveness in relation to C. albicans (32.8±7.4 mkg/ml). Advantages of the antimicrobial activity of modern antimicrobial dressings with AMC against S. aureus, E. coli, P. aeruginosa, fungi of Candida genus have been found.
References
Алгоритмы специализированной медицинской помощи больным сахарным диабетом / Под ред. И.И.Дедова, М.В.Шестаковой. – М., 2009. – 101 с.
Международное соглашение по диабетической стопе. Составлено Международной рабочей группой по диабетической стопе. – М.: Берег, 2000. – 96 с.
Некрасова Л.С., Свита В.М., Глушкевич Т.Г. та ін. Визначення чутливості мікроорганізмів до антибактеріальних препаратів: Метод. вказівки МВ 9.9.5 – 143. – К., 2007. – 74 с.
Палій Г.К., Когет Т.О., Палій В.Г. та ін. Антисептики в профілактиці і лікуванні інфекцій. – К.: Здоров’я, 1997. – 201 с.
Пат. №74853 Україна МПК А 61 L 15/12 (2006.01) Композиція для надання медичним текстильним матеріалам антимікробних властивостей з пролонгованою дією / О.А.Назарчук, В.Г.Палій, В.Д.Палій та ін.; заявник та патентовласник Вінницький нац. мед. університет ім. М.І.Пирогова. – №201205693. Заявл.: 10.05.2012. Опубл.: 12.11.2012. – Бюл. №21. – 4 с.
Steed D.L., Attinger C., Collazzi T. et al. // Wound Repair. and Regeneration. – 2006. – Vol. 14, №6. – P. 680-692.
Downloads
Published
Issue
Section
License
Copyright (c) 2014 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).